GPR123 explained
Probable G-protein coupled receptor 123 is a protein that in humans is encoded by the GPR123 gene.[1] [2] It is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[3] [4] [5]
Further reading
- Vassilatis DK, Hohmann JG, Zeng H . The G protein-coupled receptor repertoires of human and mouse . Proc. Natl. Acad. Sci. U.S.A. . 100 . 8 . 4903–8 . 2003 . 12679517 . 10.1073/pnas.0230374100 . 153653 . 2003PNAS..100.4903V . etal. free .
- Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
- Deloukas P, Earthrowl ME, Grafham DV . The DNA sequence and comparative analysis of human chromosome 10 . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . etal. free .
- Bjarnadóttir TK, Fredriksson R, Höglund PJ . The human and mouse repertoire of the adhesion family of G-protein-coupled receptors . Genomics . 84 . 1 . 23–33 . 2005 . 15203201 . 10.1016/j.ygeno.2003.12.004 . etal.
- Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
Notes and References
- Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB . There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini . Biochem Biophys Res Commun . 301 . 3 . 725–34 . Feb 2003 . 12565841 . 10.1016/S0006-291X(03)00026-3 .
- Web site: Entrez Gene: GPR123 G protein-coupled receptor 123.
- Book: Stacey M, Yona S . AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology) . Springer . Berlin . 2011 . 978-1-4419-7912-4 .
- Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB . Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions . FEBS Lett . 531 . 3 . 407–14 . Nov 2002 . 12435584 . 10.1016/S0014-5793(02)03574-3 . 7449692 . free .
- Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT . A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis . EMBO J. . 31 . 6 . 1364–78 . March 2012 . 22333914 . 3321182 . 10.1038/emboj.2012.26 .