GPR116 explained

Probable G-protein coupled receptor 116 is a protein that in humans is encoded by the GPR116 gene.^{[1] [2] [3]} GPR116 has now been shown to play an essential role in the regulation of lung surfactant homeostasis.^{[4] [5]}

Further reading

• Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA . The G protein-coupled receptor repertoires of human and mouse . Proceedings of the National Academy of Sciences of the United States of America . 100 . 8 . 4903–8 . Apr 2003 . 12679517 . 153653 . 10.1073/pnas.0230374100 . 2003PNAS..100.4903V . free .
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB . The human and mouse repertoire of the adhesion family of G-protein-coupled receptors . Genomics . 84 . 1 . 23–33 . Jul 2004 . 15203201 . 10.1016/j.ygeno.2003.12.004 .
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A . From ORFeome to biology: a functional genomics pipeline . Genome Research . 14 . 10B . 2136–44 . Oct 2004 . 15489336 . 528930 . 10.1101/gr.2576704 .

Notes and References

1. Book: Stacey, edited by S Yona, M Stacey. Adhesion-GPCRs : structure to function. 2010. Springer Science+Business Media. New York. 978-1-4419-7912-4.
2. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB . Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions . FEBS Letters . 531 . 3 . 407–14 . Nov 2002 . 12435584 . 10.1016/S0014-5793(02)03574-3 . 7449692 . free .
3. Web site: Entrez Gene: GPR116 G protein-coupled receptor 116.
4. Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B . Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116 . Cell Reports . 3 . 5 . 1457–64 . May 2013 . 23684610 . 10.1016/j.celrep.2013.04.019 . 3695742.
5. Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S . Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D . PLOS ONE . 8 . 7 . e69451 . 2013 . 23922714 . 10.1371/journal.pone.0069451 . 3726689. 2013PLoSO...869451F . free .