GPR114 explained

G protein-coupled receptor 114 is a protein encoded by the ADGRG5 gene.^{[1] [2] [3]} GPR114 is a member of the adhesion GPCR family.^{[4] [5]} Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[6]

GPR114 mRNA is specifically expressed in human eosinophils as well as in mouse lymphocytes, monocytes, macrophage, and dendritic cells.^[7]

Signaling

The cyclic adenosine monophosphate (cAMP) assay in overexpressing HEK293 cells has demonstrated coupling of GPR114 to Gα_s protein.^[8]

External links

• Adhesion GPCR consortium

Notes and References

1. Web site: Entrez Gene: GPR114 G protein-coupled receptor 114.
2. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB . Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions . FEBS Letters . 531 . 3 . 407–14 . Nov 2002 . 12435584 . 10.1016/S0014-5793(02)03574-3 . 7449692 . free .
3. Hamann. J. Aust. G. Araç. D. Engel. FB. Formstone. C. Fredriksson. R. Hall. RA. Harty. BL. Kirchhoff. C. Knapp. B. Krishnan. A. Liebscher. I. Lin. HH. Martinelli. DC. Monk. KR. Peeters. MC. Piao. X. Prömel. S. Schöneberg. T. Schwartz. TW. Singer. K. Stacey. M. Ushkaryov. YA. Vallon. M. Wolfrum. U. Wright. MW. Xu. L. Langenhan. T. Schiöth. HB. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.. Pharmacological Reviews. April 2015. 67. 2. 338–67. 25713288. 10.1124/pr.114.009647. 4394687.
4. Book: Stacey M, Yona S . Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology) . Springer . Berlin . 2011 . 978-1-4419-7912-4 .
5. Langenhan. T. Aust. G. Hamann. J. Sticky signaling--adhesion class G protein-coupled receptors take the stage.. Science Signaling. 21 May 2013. 6. 276. re3. 23695165. 10.1126/scisignal.2003825. 6958640.
6. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT . A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis . The EMBO Journal . 31 . 6 . 1364–78 . Mar 2012 . 22333914 . 3321182 . 10.1038/emboj.2012.26 .
7. Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB . International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors . Pharmacological Reviews . 67 . 2 . 338–67 . Apr 2015 . 25713288 . 10.1124/pr.114.009647 . 4394687.
8. Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X . Signaling property study of adhesion G-protein-coupled receptors . FEBS Letters . 586 . 8 . 1214–9 . Apr 2012 . 22575658 . 10.1016/j.febslet.2012.03.014 . 3020230 . free .