GPR112 explained

G protein-coupled receptor 112 is a protein encoded by the ADGRG4 gene.^{[1] [2]} GPR112 is a member of the adhesion GPCR family.^{[3] [4]} Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[5]

GPR112 is expressed in human enterochromaffin cells^[6] and in the mouse intestine.^[7] The N-terminal fragment (NTF) of GPR112 contains pentraxin (PTX)-like modules.^[7] GPR112 gene expression has been identified as a marker for neuroendocrine carcinoma cells.^[6]

External links

• Adhesion GPCR consortium

Notes and References

1. Web site: Entrez Gene: GPR112 G protein-coupled receptor 112.
2. Hamann. J. Aust. G. Araç. D. Engel. FB. Formstone. C. Fredriksson. R. Hall. RA. Harty. BL. Kirchhoff. C. Knapp. B. Krishnan. A. Liebscher. I. Lin. HH. Martinelli. DC. Monk. KR. Peeters. MC. Piao. X. Prömel. S. Schöneberg. T. Schwartz. TW. Singer. K. Stacey. M. Ushkaryov. YA. Vallon. M. Wolfrum. U. Wright. MW. Xu. L. Langenhan. T. Schiöth. HB. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.. Pharmacological Reviews. April 2015. 67. 2. 338–67. 25713288. 10.1124/pr.114.009647. 4394687.
3. Book: Stacey M, Yona S . Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology) . Springer . Berlin . 2011 . 978-1-4419-7912-4 .
4. Langenhan. T. Aust. G. Hamann. J. Sticky signaling--adhesion class G protein-coupled receptors take the stage.. Science Signaling. 21 May 2013. 6. 276. re3. 23695165. 10.1126/scisignal.2003825. 6958640.
5. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT . A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis . The EMBO Journal . 31 . 6 . 1364–78 . Mar 2012 . 22333914 . 3321182 . 10.1038/emboj.2012.26 .
6. Leja J, Essaghir A, Essand M, Wester K, Oberg K, Tötterman TH, Lloyd R, Vasmatzis G, Demoulin JB, Giandomenico V . Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas . Modern Pathology . 22 . 2 . 261–72 . Feb 2009 . 18953328 . 10.1038/modpathol.2008.174 . 22334557 .
7. Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB . International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors . Pharmacological Reviews . 67 . 2 . 338–67 . Apr 2015 . 25713288 . 10.1124/pr.114.009647 . 4394687.