GPR110 explained

Probable G-protein coupled receptor 110 is a protein that in humans is encoded by the GPR110 gene.^{[1] [2]} This gene encodes a member of the adhesion-GPCR receptor family.^[3] Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[4]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . vanc. Yoshitomo-Nakagawa K . Maruyama K . 3 . Suyama . A . Sugano . S .
• Takeda S . Identification of G protein-coupled receptor genes from the human genome sequence . FEBS Lett. . 520 . 1–3 . 97–101 . 2002 . 12044878 . 10.1016/S0014-5793(02)02775-8 . vanc. Kadowaki S . Haga T . 3 . Takaesu . H . Mitaku . S . 7116392 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Vassilatis DK . The G protein-coupled receptor repertoires of human and mouse . Proc. Natl. Acad. Sci. U.S.A. . 100 . 8 . 4903–8 . 2003 . 12679517 . 10.1073/pnas.0230374100 . 153653 . vanc. Hohmann JG . Zeng H . 3 . Li . F . Ranchalis . JE . Mortrud . MT . Brown . A . Rodriguez . SS . Weller . JR . 2003PNAS..100.4903V . free .
• Mungall AJ . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . vanc. Palmer SA . Sims SK . 3 . Edwards . C. A. . Ashurst . J. L. . Wilming . L. . Jones . M. C. . Horton . R. . Hunt . S. E. . 2003Natur.425..805M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Bjarnadóttir TK . The human and mouse repertoire of the adhesion family of G-protein-coupled receptors . Genomics . 84 . 1 . 23–33 . 2005 . 15203201 . 10.1016/j.ygeno.2003.12.004 . vanc. Fredriksson R . Höglund PJ . 3 . Gloriam . David E. . Lagerström . Malin C. . Schiöth . Helgi B. .

Notes and References

1. Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB . Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions . FEBS Lett . 531 . 3 . 407–14 . Nov 2002 . 12435584 . 10.1016/S0014-5793(02)03574-3 . 7449692 . free .
2. Web site: Entrez Gene: GPR110 G protein-coupled receptor 110.
3. Book: Stacey M, Yona S . Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology) . Springer . Berlin . 2011 . 978-1-4419-7912-4 .
4. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT . A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis . EMBO J. . 31 . 6 . 1364–78 . March 2012 . 22333914 . 3321182 . 10.1038/emboj.2012.26 .