GPR1 explained

G protein-coupled receptor 1, also known as GPR1, is a protein that in humans is encoded by the GPR1 gene.^{[1] [2]}

GPR1 is a member of the G protein-coupled receptor family of transmembrane receptors. It functions as a receptor for chemerin.^[3] Other receptors for chemerin include CMKLR1 and CCRL2.

Further reading

• Shimizu N . An Orphan G Protein-Coupled Receptor, GPR1, Acts as a Coreceptor To Allow Replication of Human Immunodeficiency Virus Types 1 and 2 in Brain-Derived Cells . J. Virol. . 73 . 6 . 5231–9 . 1999 . 10233994 . 10.1128/JVI.73.6.5231-5239.1999. 112576 . vanc. Soda Y . Kanbe K . 3 . Liu . HY . Jinno . A . Kitamura . T . Hoshino . H .
• Tokizawa S . Infection of mesangial cells with HIV and SIV: identification of GPR1 as a coreceptor . Kidney Int. . 58 . 2 . 607–17 . 2000 . 10916084 . 10.1046/j.1523-1755.2000.00207.x . vanc. Shimizu N . Hui-Yu L . 3 . Deyu . Fang . Haraguchi . Yuji . Oite . Takashi . Hoshino . Hiroo . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Kang MK . Senescence-associated genes in normal human oral keratinocytes . Exp. Cell Res. . 287 . 2 . 272–81 . 2003 . 12837283 . 10.1016/S0014-4827(03)00061-2 . vanc. Kameta A . Shin KH . 3 . Baluda . MA . Kim . HR . Park . NH .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Hillier LW . Generation and annotation of the DNA sequences of human chromosomes 2 and 4 . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . vanc. Graves TA . Fulton RS . 3 . Fulton . Lucinda A. . Pepin . Kymberlie H. . Minx . Patrick . Wagner-Mcpherson . Caryn . Layman . Dan . Wylie . Kristine . 2005Natur.434..724H . free .
• Jinno-Oue A . The synthetic peptide derived from the NH2-terminal extracellular region of an orphan G protein-coupled receptor, GPR1, preferentially inhibits infection of X4 HIV-1 . J. Biol. Chem. . 280 . 35 . 30924–34 . 2005 . 15919664 . 10.1074/jbc.M500195200 . vanc. Shimizu N . Soda Y . 3 . Tanaka . A . Ohtsuki . T . Kurosaki . D . Suzuki . Y . Hoshino . H . free .
• Otsuki T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . vanc. Ota T . Nishikawa T . 3 . Hayashi . K . Suzuki . Y . Yamamoto . J . Wakamatsu . A . Kimura . K . Sakamoto . K . free .
• Kimura K . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . vanc. Wakamatsu A . Suzuki Y . 3 . Ota . T . Nishikawa . T . Yamashita . R . Yamamoto . J . Sekine . M . Tsuritani . K .

Notes and References

1. Web site: Entrez Gene: GPR1 G protein-coupled receptor 1.
2. Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF . Cloning of human genes encoding novel G protein-coupled receptors . Genomics . 23 . 3 . 609–18 . October 1994 . 7851889 . 10.1006/geno.1994.1549 .
3. Barnea G, Strapps W, Herrada G, Berman Y, Ong J, Kloss B, Axel R, Lee KJ . The genetic design of signaling cascades to record receptor activation . Proc. Natl. Acad. Sci. U.S.A. . 105 . 1 . 64–9 . January 2008 . 18165312 . 2224232 . 10.1073/pnas.0710487105 . free .