Glypican 6 Explained

Glypican-6 is a protein that in humans is encoded by the GPC6 gene.^{[1] [2]}

The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans. The glypicans have been implicated in the control of cell growth and division. Glypican 6 is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases.

See also

• Glypican

Further reading

• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Dunham A, Matthews LH, Burton J, etal . The DNA sequence and analysis of human chromosome 13 . Nature . 428 . 6982 . 522–8 . 2004 . 15057823 . 10.1038/nature02379 . 2665288 . 2004Natur.428..522D .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Veugelers M, De Cat B, Ceulemans H, etal . Glypican-6, a new member of the glypican family of cell surface heparan sulfate proteoglycans . J. Biol. Chem. . 274 . 38 . 26968–77 . 1999 . 10480909 . 10.1074/jbc.274.38.26968 . free .
• Watanabe K, Yamada H, Yamaguchi Y . K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney . J. Cell Biol. . 130 . 5 . 1207–18 . 1995 . 7657705 . 10.1083/jcb.130.5.1207 . 2120559 .

Notes and References

1. Paine-Saunders S, Viviano BL, Saunders S . GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13 . Genomics . 57 . 3 . 455–8 . Aug 1999 . 10329016 . 10.1006/geno.1999.5793 .
2. Web site: Entrez Gene: GPC6 glypican 6.