GPAM explained

Glycerol-3-phosphate acyltransferase 1, mitochondrial is an enzyme that in humans is encoded by the GPAM gene.^{[1] [2] [3]}

Glycerol-3-phosphate acyltransferase (GPAT; EC 2.3.1.15), which catalyzes the initial and committing step in glycerolipid biosynthesis, is predicted to play a pivotal role in the regulation of cellular triacylglycerol and phospholipid levels. Two mammalian forms of GPAT have been identified on the basis of localization to either the endoplasmic reticulum or mitochondria.[supplied by OMIM]

Further reading

• Skorve J . Effect of 3- and 4-thia-substituted fatty acids on glycerolipid metabolism and mitochondrial beta-oxidation in rat liver . Biochem. Pharmacol. . 40 . 9 . 2005–2012 . 1990 . 2242030 . 10.1016/0006-2952(90)90230-I . vanc. Ruyter B . Rustan AC . 3 . Christiansen . E . Drevon . C . Berge . R .
• Thomas PD, Poznansky MJ . Lipid peroxidation inactivates rat liver microsomal glycerol-3-phosphate acyl transferase. Effect of iron and copper salts and carbon tetrachloride . J. Biol. Chem. . 265 . 5 . 2684–91 . 1990 . 10.1016/S0021-9258(19)39856-4 . 2303421 . free .
• Welch CL . Assignment of Gpam to distal mouse chromosome 19 by linkage analysis . Mamm. Genome . 9 . 1 . 93 . 1998 . 9434961 . 10.1007/s003359900694 . vanc. Xia YR . Edwards PA . 3 . Lusis . Aidons J. . Ericsson . Johan . 20038636 .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Res. . 10 . 11 . 1788–1795 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res. . 11 . 3 . 422–435 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 . vanc. Weil B . Wellenreuther R . 3 . Gassenhuber . J . Glassl . S . Ansorge . W . Böcher . M . Blöcker . H . Bauersachs . S .
• Igal RA, Wang S, Gonzalez-Baró M, Coleman RA . Mitochondrial glycerol phosphate acyltransferase directs the incorporation of exogenous fatty acids into triacylglycerol . J. Biol. Chem. . 276 . 45 . 42205–42212 . 2001 . 11546763 . 10.1074/jbc.M103386200 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Deloukas P . The DNA sequence and comparative analysis of human chromosome 10 . Nature . 429 . 6990 . 375–381 . 2004 . 15164054 . 10.1038/nature02462 . vanc. Earthrowl ME . Grafham DV . 3 . Rubenfield . M. . French . L. . Steward . C. A. . Sims . S. K. . Jones . M. C. . Searle . S. . 2004Natur.429..375D . free .
• Wiemann S . From ORFeome to biology: a functional genomics pipeline . Genome Res. . 14 . 10B . 2136–2144 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 . vanc. Arlt D . Huber W . 3 . Wellenreuther . R . Schleeger . S . Mehrle . A . Bechtel . S . Sauermann . M . Korf . U .
• Mehrle A . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–D418 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 . vanc. Rosenfelder H . Schupp I . 3 . Del Val . C . Arlt . D . Hahne . F . Bechtel . S . Simpson . J . Hofmann . O .

Notes and References

1. Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O . Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 7 . 4 . 273–81 . Dec 2000 . 10997877 . 10.1093/dnares/7.4.271. free .
2. Yet SF, Lee S, Hahm YT, Sul HS . Expression and identification of p90 as the murine mitochondrial glycerol-3-phosphate acyltransferase . Biochemistry . 32 . 36 . 9486–9491 . Oct 1993 . 8369314 . 10.1021/bi00087a029 .
3. Web site: Entrez Gene: GPAM glycerol-3-phosphate acyltransferase, mitochondrial.