GPA33 explained

Cell surface A33 antigen is a protein that in humans is encoded by the GPA33 gene.^{[1] [2] [3]}

The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily.

Further reading

• Hwang SH, Sohn YH, Oh HB . Human leukocyte antigen alleles and haplotypes associated with chronicity of hepatitis B virus infection in Koreans. . Arch. Pathol. Lab. Med. . 131 . 1 . 117–21 . 2007 . 17227111 . 10.5858/2007-131-117-HLAAAH. etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Mao Z, Song S, Zhu Y . Transcriptional regulation of A33 antigen expression by gut-enriched Krüppel-like factor. . Oncogene . 22 . 28 . 4434–43 . 2003 . 12853980 . 10.1038/sj.onc.1206508 . 38283384 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Johnstone CN, White SJ, Tebbutt NC . Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression. . J. Biol. Chem. . 277 . 37 . 34531–9 . 2002 . 12114523 . 10.1074/jbc.M204865200 . 36386508 . etal. free .
• Moritz RL, Ritter G, Catimel B . Micro-sequencing strategies for the human A33 antigen, a novel surface glycoprotein of human gastrointestinal epithelium. . Journal of Chromatography A . 798 . 1–2 . 91–101 . 1998 . 9542130 . 10.1016/S0021-9673(97)01031-5 . etal.

Notes and References

1. Heath JK, White SJ, Johnstone CN, Catimel B, Simpson RJ, Moritz RL, Tu GF, Ji H, Whitehead RH, Groenen LC, Scott AM, Ritter G, Cohen L, Welt S, Old LJ, Nice EC, Burgess AW . The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily . Proc Natl Acad Sci U S A . 94 . 2 . 469–74 . Mar 1997 . 9012807 . 19536 . 10.1073/pnas.94.2.469 . 1997PNAS...94..469H . free .
2. Ritter G, Cohen LS, Nice EC, Catimel B, Burgess AW, Moritz RL, Ji H, Heath JK, White SJ, Welt S, Old LJ, Simpson RJ . Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium . Biochem Biophys Res Commun . 236 . 3 . 682–6 . Sep 1997 . 9245713 . 10.1006/bbrc.1997.6966 .
3. Web site: Entrez Gene: GPA33 glycoprotein A33 (transmembrane).