GOSR1 explained

Golgi SNAP receptor complex member 1 is a protein that in humans is encoded by the GOSR1 gene.^{[1] [2] [3] [4]}

This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi apparatus and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Interactions

GOSR1 has been shown to interact with USO1,^[5] BET1L^{[5] [6]} and STX5.^{[5] [7] [8] [9]}

Further reading

• Nagahama M, Orci L, Ravazzola M, Amherdt M, Lacomis L, Tempst P, Rothman JE, Söllner TH . A v-SNARE implicated in intra-Golgi transport . The Journal of Cell Biology . 133 . 3 . 507–16 . May 1996 . 8636227 . 2120813 . 10.1083/jcb.133.3.507 .
• Hay JC, Chao DS, Kuo CS, Scheller RH . Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells . Cell . 89 . 1 . 149–58 . Apr 1997 . 9094723 . 10.1016/S0092-8674(00)80191-9 . 8682509 . free .
• Subramaniam VN, Loh E, Hong W . N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex . The Journal of Biological Chemistry . 272 . 41 . 25441–4 . Oct 1997 . 9325254 . 10.1074/jbc.272.41.25441 . 12818072 . free .
• Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH . Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs . The Journal of Cell Biology . 141 . 7 . 1489–502 . Jun 1998 . 9647643 . 2133002 . 10.1083/jcb.141.7.1489 .
• Bui TD, Levy ER, Subramaniam VN, Lowe SL, Hong W . cDNA characterization and chromosomal mapping of human golgi SNARE GS27 and GS28 to chromosome 17 . Genomics . 57 . 2 . 285–8 . Apr 1999 . 10198168 . 10.1006/geno.1998.5649 .
• Sagiv Y, Legesse-Miller A, Porat A, Elazar Z . GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28 . The EMBO Journal . 19 . 7 . 1494–504 . Apr 2000 . 10747018 . 310219 . 10.1093/emboj/19.7.1494 .
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Research . 10 . 10 . 1546–60 . Oct 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
• Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G . Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115 . The Journal of Cell Biology . 157 . 1 . 45–62 . Apr 2002 . 11927603 . 2173270 . 10.1083/jcb.200112127 .
• Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA . IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells . Immunity . 16 . 6 . 779–90 . Jun 2002 . 12121660 . 10.1016/S1074-7613(02)00324-2 . free .
• Xu Y, Martin S, James DE, Hong W . GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus . Molecular Biology of the Cell . 13 . 10 . 3493–507 . Oct 2002 . 12388752 . 129961 . 10.1091/mbc.E02-01-0004 .
• Tai G, Lu L, Wang TL, Tang BL, Goud B, Johannes L, Hong W . Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network . Molecular Biology of the Cell . 15 . 9 . 4011–22 . Sep 2004 . 15215310 . 515336 . 10.1091/mbc.E03-12-0876 .
• Arasaki K, Taniguchi M, Tani K, Tagaya M . RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex . Molecular Biology of the Cell . 17 . 6 . 2780–8 . Jun 2006 . 16571679 . 1474792 . 10.1091/mbc.E05-10-0973 .

Notes and References

1. Subramaniam VN, Peter F, Philp R, Wong SH, Hong W . GS28, a 28-kilodalton Golgi SNARE that participates in ER-Golgi transport . Science . 272 . 5265 . 1161–3 . May 1996 . 8638159 . 10.1126/science.272.5265.1161 . 1996Sci...272.1161S . 42813531 .
2. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z . Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning . Proceedings of the National Academy of Sciences of the United States of America . 95 . 14 . 8175–80 . Jul 1998 . 9653160 . 20949 . 10.1073/pnas.95.14.8175 . 1998PNAS...95.8175M . free .
3. Oka T, Ungar D, Hughson FM, Krieger M . The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins . Molecular Biology of the Cell . 15 . 5 . 2423–35 . May 2004 . 15004235 . 404034 . 10.1091/mbc.E03-09-0699 .
4. Web site: Entrez Gene: GOSR1 golgi SNAP receptor complex member 1.
5. Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G . Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115 . The Journal of Cell Biology . 157 . 1 . 45–62 . Apr 2002 . 11927603 . 2173270 . 10.1083/jcb.200112127 .
6. Xu Y, Martin S, James DE, Hong W . GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus . Molecular Biology of the Cell . 13 . 10 . 3493–507 . Oct 2002 . 12388752 . 129961 . 10.1091/mbc.E02-01-0004 .
7. Hay JC, Chao DS, Kuo CS, Scheller RH . Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells . Cell . 89 . 1 . 149–58 . Apr 1997 . 9094723 . 10.1016/S0092-8674(00)80191-9 . 8682509 . free .
8. Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH . Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs . The Journal of Cell Biology . 141 . 7 . 1489–502 . Jun 1998 . 9647643 . 2133002 . 10.1083/jcb.141.7.1489 .
9. Subramaniam VN, Loh E, Hong W . N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex . The Journal of Biological Chemistry . 272 . 41 . 25441–4 . Oct 1997 . 9325254 . 10.1074/jbc.272.41.25441 . 12818072 . free .