GOLGA5 explained

Golgin subfamily A member 5 is a protein that in humans is encoded by the GOLGA5 gene.^{[1] [2] [3] [4]}

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins, whose members localize to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5.

Interactions

GOLGA5 has been shown to interact with RAB1A.^{[5] [6]}

Further reading

• Short B, Barr FA . Membrane traffic: a glitch in the Golgi matrix. . Curr. Biol. . 13 . 8 . R311–3 . 2004 . 12699642 . 10.1016/S0960982203002343 . free .
• Bascom RA, Srinivasan S, Nussbaum RL . Identification and characterization of golgin-84, a novel Golgi integral membrane protein with a cytoplasmic coiled-coil domain. . J. Biol. Chem. . 274 . 5 . 2953–62 . 1999 . 9915833 . 10.1074/jbc.274.5.2953 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Heilig R, Eckenberg R, Petit JL . The DNA sequence and analysis of human chromosome 14. . Nature . 421 . 6923 . 601–7 . 2003 . 12508121 . 10.1038/nature01348 . etal. 2003Natur.421..601H . free .
• Diao A, Rahman D, Pappin DJ . The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation. . J. Cell Biol. . 160 . 2 . 201–12 . 2003 . 12538640 . 10.1083/jcb.200207045 . 2172652 . etal.
• Satoh A, Wang Y, Malsam J . Golgin-84 is a rab1 binding partner involved in Golgi structure. . Traffic . 4 . 3 . 153–61 . 2003 . 12656988 . 10.1034/j.1600-0854.2003.00103.x . etal . 3282115.
• Brill LM, Salomon AR, Ficarro SB . Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. . Anal. Chem. . 76 . 10 . 2763–72 . 2004 . 15144186 . 10.1021/ac035352d . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rush J, Moritz A, Lee KA . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 . etal.
• Malsam J, Satoh A, Pelletier L, Warren G . Golgin tethers define subpopulations of COPI vesicles. . Science . 307 . 5712 . 1095–8 . 2005 . 15718469 . 10.1126/science.1108061 . 2005Sci...307.1095M . 12601850 .
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . etal. free .

Notes and References

1. Ishizaka Y, Ochiai M, Tahira T, Sugimura T, Nagao M . Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicing . Oncogene . 4 . 6 . 789–94 . Jul 1989 . 2734021 .
2. Klugbauer S, Demidchik EP, Lengfelder E, Rabes HM . Detection of a novel type of RET rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved RET-fused gene RFG5 . Cancer Res . 58 . 2 . 198–203 . Feb 1998 . 9443391 .
3. Oka T, Ungar D, Hughson FM, Krieger M . The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins . Mol Biol Cell . 15 . 5 . 2423–35 . Apr 2004 . 15004235 . 404034 . 10.1091/mbc.E03-09-0699 .
4. Web site: Entrez Gene: GOLGA5 golgi autoantigen, golgin subfamily a, 5.
5. 10.1034/j.1600-0854.2003.00103.x . Satoh . Ayano . Wang Yanzhuang . Malsam Jörg . Beard Matthew B . Warren Graham . Mar 2003 . Golgin-84 is a rab1 binding partner involved in Golgi structure . Traffic . 4 . 3 . 153–61 . Denmark. 1398-9219. 12656988 . 3282115.
6. Diao . Aipo . Rahman Dinah . Pappin Darryl J C . Lucocq John . Lowe Martin . Jan 2003 . The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation . J. Cell Biol. . 160 . 2 . 201–12 . United States. 0021-9525. 12538640 . 10.1083/jcb.200207045 . 2172652 .