GOLGA4 explained

Golgin subfamily A member 4 is a protein that in humans is encoded by the GOLGA4 gene.^[1]

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternative splice variants have been described but their full-length nature has not been determined.^[2]

Interactions

GOLGA4 has been shown to interact with ARL1.^{[3] [4]}

Further reading

• Kooy J, Toh BH, Pettitt JM . Human autoantibodies as reagents to conserved Golgi components. Characterization of a peripheral, 230-kDa compartment-specific Golgi protein . J. Biol. Chem. . 267 . 28 . 20255–20263 . 1992 . 10.1016/S0021-9258(19)88694-5 . 1400343 . etal. free .
• Fritzler MJ, Lung CC, Hamel JC . Molecular characterization of Golgin-245, a novel Golgi complex protein containing a granin signature . J. Biol. Chem. . 270 . 52 . 31262–31268 . 1996 . 8537393 . 10.1074/jbc.270.52.31262 . etal. free .
• Gleeson PA, Anderson TJ, Stow JL . p230 is associated with vesicles budding from the trans-Golgi network . J. Cell Sci. . 109 . 12. 2811–2821 . 1997 . 10.1242/jcs.109.12.2811 . 9013329 . etal.
• Barr FA . A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins . Curr. Biol. . 9 . 7 . 381–384 . 1999 . 10209123 . 10.1016/S0960-9822(99)80167-5 . 14404566 . free . 1999CBio....9..381B .
• Daigo Y, Isomura M, Nishiwaki T . Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3 . DNA Res. . 6 . 1 . 37–44 . 1999 . 10231028 . 10.1093/dnares/6.1.37 . etal. free .
• Eichmuller S, Usener D, Dummer R . Serological detection of cutaneous T-cell lymphoma-associated antigens . Proc. Natl. Acad. Sci. U.S.A. . 98 . 2 . 629–634 . 2001 . 11149944 . 10.1073/pnas.021386498 . 14639 . etal. free .
• Van Valkenburgh H, Shern JF, Sharer JD . ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins . J. Biol. Chem. . 276 . 25 . 22826–22837 . 2001 . 11303027 . 10.1074/jbc.M102359200 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Lu L, Hong W . Interaction of Arl1-GTP with GRIP Domains Recruits Autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi . Mol. Biol. Cell . 14 . 9 . 3767–3781 . 2004 . 12972563 . 10.1091/mbc.E03-01-0864 . 196566 .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Anderson NL, Polanski M, Pieper R . The human plasma proteome: a nonredundant list developed by combination of four separate sources . Mol. Cell. Proteomics . 3 . 4 . 311–326 . 2004 . 14718574 . 10.1074/mcp.M300127-MCP200 . etal. free .
• Wu M, Lu L, Hong W, Song H . Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1 . Nat. Struct. Mol. Biol. . 11 . 1 . 86–94 . 2004 . 14718928 . 10.1038/nsmb714 . 25799841 .
• Kakinuma T, Ichikawa H, Tsukada Y . Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery . Exp. Cell Res. . 298 . 2 . 388–398 . 2004 . 15265687 . 10.1016/j.yexcr.2004.04.047 . etal.
• Beausoleil SA, Jedrychowski M, Schwartz D . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–12135 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . etal. 2004PNAS..10112130B . free .
• Luke MR, Houghton F, Perugini MA, Gleeson PA . The trans-Golgi network GRIP-domain proteins form α-helical homodimers . Biochem. J. . 388 . Pt 3 . 835–841 . 2005 . 15654769 . 10.1042/BJ20041810 . 1183463 .
• Yoshino A, Setty SR, Poynton C . tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre . J. Cell Sci. . 118 . Pt 10 . 2279–2293 . 2006 . 15870108 . 10.1242/jcs.02358 . 22690784 . etal.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–648 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .

Notes and References

1. Erlich R, Gleeson PA, Campbell P, Dietzsch E, Toh BH . Molecular characterization of trans-Golgi p230. A human peripheral membrane protein encoded by a gene on chromosome 6p12-22 contains extensive coiled-coil alpha-helical domains and a granin motif . J Biol Chem . 271 . 14 . 8328–8337 . June 1996. 8626529 . 10.1074/jbc.271.14.8328. free .
2. Web site: Entrez Gene: GOLGA4 golgi autoantigen, golgin subfamily a, 4.
3. Lu . Lei . Hong Wanjin . September 2003. Interaction of Arl1-GTP with GRIP Domains Recruits Autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi . Mol. Biol. Cell . 14 . 9 . 3767–3781 . 1059-1524. 12972563 . 10.1091/mbc.E03-01-0864 . 196566 .
4. Van Valkenburgh . H . Shern J F . Sharer J D . Zhu X . Kahn R A . June 2001. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins . J. Biol. Chem. . 276 . 25 . 22826–22837 . 0021-9258. 11303027 . 10.1074/jbc.M102359200 . free .