GOLGA1 explained

Golgin subfamily A member 1 is a protein that in humans is encoded by the GOLGA1 gene.^{[1] [2]}

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. This encoded protein is associated with Sjogren's syndrome.

Interactions

GOLGA1 has been shown to interact with ARL1.^[3]

Further reading

• Barr FA . A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins . Current Biology . 9 . 7 . 381–384 . April 1999 . 10209123 . 10.1016/S0960-9822(99)80167-5 . 14404566 . free . 1999CBio....9..381B .
• Lu L, Hong W . Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi . Molecular Biology of the Cell . 14 . 9 . 3767–3781 . September 2003 . 12972563 . 196566 . 10.1091/mbc.E03-01-0864 .
• Lu L, Tai G, Hong W . Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network . Molecular Biology of the Cell . 15 . 10 . 4426–4443 . October 2004 . 15269279 . 519138 . 10.1091/mbc.E03-12-0872 .
• Luke MR, Houghton F, Perugini MA, Gleeson PA . The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers . The Biochemical Journal . 388 . Pt 3 . 835–841 . June 2005 . 15654769 . 1183463 . 10.1042/BJ20041810 .
• Lock JG, Hammond LA, Houghton F, Gleeson PA, Stow JL . E-cadherin transport from the trans-Golgi network in tubulovesicular carriers is selectively regulated by golgin-97 . Traffic . 6 . 12 . 1142–1156 . December 2005 . 16262725 . 10.1111/j.1600-0854.2005.00349.x . 32851401 . free .
• Alzhanova D, Hruby DE . A host cell membrane protein, golgin-97, is essential for poxvirus morphogenesis . Virology . 362 . 2 . 421–427 . June 2007 . 17276477 . 2680701 . 10.1016/j.virol.2007.01.003 .

Notes and References

1. Griffith KJ, Chan EK, Lung CC, Hamel JC, Guo X, Miyachi K, Fritzler MJ . Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjögren's syndrome . Arthritis and Rheumatism . 40 . 9 . 1693–1702 . September 1997 . 9324025 . 10.1002/art.1780400920 . free .
2. Web site: Entrez Gene: GOLGA1 golgi autoantigen, golgin subfamily a, 1.
3. Lu L, Hong W . Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi . Molecular Biology of the Cell . 14 . 9 . 3767–3781 . September 2003 . 12972563 . 196566 . 10.1091/mbc.E03-01-0864 .