GNRHR2 explained

Putative gonadotropin-releasing hormone II receptor is a protein that in humans is encoded by the GNRHR2 gene.[1] [2]

Function

The receptor for gonadotropin-releasing hormone 2 (GnRH2) is encoded by the GnRH2 receptor (GnRHR2) gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembrane G protein-coupled receptor. However, in humans, the N-terminus of the predicted protein contains a frameshift and premature stop codon. In humans, GnRHR2 transcription occurs but whether the gene produces a functional C-terminal multi-transmembrane protein is currently unresolved. Alternative splice variants have been reported. An untranscribed pseudogene of GnRHR2 is also on chromosome 14.[2]

See also

Further reading

External links

Notes and References

  1. Faurholm B, Millar RP, Katz AA . The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci . Genomics . 78 . 1–2 . 15–8 . Nov 2001 . 11707068 . 10.1006/geno.2001.6650 .
  2. Web site: Entrez Gene: GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2.