GNA11 explained

Guanine nucleotide-binding protein subunit alpha-11 is a protein that in humans is encoded by the GNA11 gene.^{[1] [2]} Together with GNAQ (its paralogue), it functions as a Gq alpha subunit.^[3]

See also

• Gq alpha subunit

Further reading

• Raymond JR, Mukhin YV, Gelasco A . Multiplicity of mechanisms of serotonin receptor signal transduction. . Pharmacol. Ther. . 92 . 2–3 . 179–212 . 2002 . 11916537 . 10.1016/S0163-7258(01)00169-3 . etal.
• Jiang M, Pandey S, Tran VT, Fong HK . Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells . Proc. Natl. Acad. Sci. U.S.A. . 88 . 9 . 3907–11 . 1991 . 1902575 . 10.1073/pnas.88.9.3907 . 51562 . 1991PNAS...88.3907J . free .
• Thomas CP, Dunn MJ, Mattera R . Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways . Biochem. J. . 312 . 1. 151–8 . 1996 . 7492305 . 10.1042/bj3120151. 1136238 .
• Offermanns S, Simon MI . G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C . J. Biol. Chem. . 270 . 25 . 15175–80 . 1995 . 7797501 . 10.1074/jbc.270.25.15175 . free .
• Stanners J, Kabouridis PS, McGuire KL, Tsoukas CD . Interaction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signaling . J. Biol. Chem. . 270 . 51 . 30635–42 . 1996 . 8530500 . 10.1074/jbc.270.51.30635 . free .
• Laugwitz KL, Allgeier A, Offermanns S . The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families . Proc. Natl. Acad. Sci. U.S.A. . 93 . 1 . 116–20 . 1996 . 8552586 . 10.1073/pnas.93.1.116 . 40189 . 1996PNAS...93..116L . etal. free .
• Launay JM, Birraux G, Bondoux D . Ras involvement in signal transduction by the serotonin 5-HT2B receptor . J. Biol. Chem. . 271 . 6 . 3141–7 . 1996 . 8621713 . 10.1074/jbc.271.6.3141 . etal. free .
• Johnson GJ, Leis LA, Dunlop PC . Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences . Biochem. J. . 318 . 3. 1023–31 . 1996 . 8836152 . 10.1042/bj3181023. 1217719 .
• Kinsella BT, O'Mahony DJ, Fitzgerald GA . The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha . J. Pharmacol. Exp. Ther. . 281 . 2 . 957–64 . 1997 . 9152406 .
• Wise A, Parenti M, Milligan G . Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association . FEBS Lett. . 407 . 3 . 257–60 . 1997 . 9175863 . 10.1016/S0014-5793(97)00300-1 . 85622146 .
• Carrasco MP, Asbóth G, Phaneuf S, López Bernal A . Activation of the prostaglandin FP receptor in human granulosa cells . J. Reprod. Fertil. . 111 . 2 . 309–17 . 1998 . 9462300 . 10.1530/jrf.0.1110309. free .
• Qian A, Wang W, Sanborn BM . Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11) . Cell. Signal. . 10 . 2 . 101–5 . 1998 . 9481484 . 10.1016/S0898-6568(97)00097-1 .
• Dulin NO, Sorokin A, Reed E . RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11 . Mol. Cell. Biol. . 19 . 1 . 714–23 . 1999 . 9858594 . 10.1128/MCB.19.1.714. 83928 . etal.
• Hayes JS, Lawler OA, Walsh MT, Kinsella BT . The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling . J. Biol. Chem. . 274 . 34 . 23707–18 . 1999 . 10446129 . 10.1074/jbc.274.34.23707 . free .
• Brydon L, Roka F, Petit L . Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins . Mol. Endocrinol. . 13 . 12 . 2025–38 . 2000 . 10598579 . 10.1210/mend.13.12.0390 . etal. free .
• Corbetta S, Mantovani G, Lania A . Calcium-sensing receptor expression and signalling in human parathyroid adenomas and primary hyperplasia . Clin. Endocrinol. . 52 . 3 . 339–48 . 2000 . 10718832 . 10.1046/j.1365-2265.2000.00933.x . 39998840 . etal.
• Shraga-Levine Z, Sokolovsky M . Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific . Cell. Mol. Neurobiol. . 20 . 3 . 305–17 . 2000 . 10789830 . 10.1023/A:1007010125316 . 21841332 .
• AbdAlla S, Lother H, Abdel-tawab AM, Quitterer U . The angiotensin II AT2 receptor is an AT1 receptor antagonist . J. Biol. Chem. . 276 . 43 . 39721–6 . 2001 . 11507095 . 10.1074/jbc.M105253200 . free .

Notes and References

1. Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI . Evolution of the mammalian G protein alpha subunit multigene family . Nat Genet . 1 . 2 . 85–91 . Jun 1993 . 1302014 . 10.1038/ng0592-85 . 31888533 . etal.
2. Web site: Entrez Gene: GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class).
3. http://www.omim.org/entry/139313 139313 GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-11; GNA11