GMEB2 explained
Glucocorticoid modulatory element-binding protein 2 is a protein that in humans is encoded by the GMEB2 gene.[1] [2] [3]
This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites.[4]
Further reading
- Nagase T, Ishikawa K, Kikuno R . Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 6 . 5 . 337–45 . 2000 . 10574462 . 10.1093/dnares/6.5.337 . etal. free .
- Kaul S, Blackford JA, Chen J . Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins. . Mol. Endocrinol. . 14 . 7 . 1010–27 . 2000 . 10894151 . 10.1210/me.14.7.1010 . etal. free .
- Deloukas P, Matthews LH, Ashurst J . The DNA sequence and comparative analysis of human chromosome 20. . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . etal. free .
- Kaul S, Blackford JA, Cho S, Simons SS . Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors. . J. Biol. Chem. . 277 . 15 . 12541–9 . 2002 . 11812797 . 10.1074/jbc.M112330200 . free .
- Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
- Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
- Lim J, Hao T, Shaw C . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . etal. free .
Notes and References
- Christensen J, Cotmore SF, Tattersall P . Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites . Mol Cell Biol . 19 . 11 . 7741–50 . Nov 1999 . 10523663 . 84824 . 10.1128/MCB.19.11.7741.
- Burnett E, Christensen J, Tattersall P . A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters . J Mol Biol . 314 . 5 . 1029–39 . Dec 2001 . 11743720 . 10.1006/jmbi.2000.5198 .
- Web site: Entrez Gene: GMEB2 glucocorticoid modulatory element binding protein 2.
- Web site: Entrez Gene: GMEB2 glucocorticoid modulatory element binding protein 2.
