GLYCAM1 explained

Glycosylation-dependent cell adhesion molecule-1 (GLYCAM1) is a proteoglycan ligand expressed on cells of the high endothelial venules in lymphoid tissues. It is the ligand for the receptor L-selectin allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues.[1] [2] GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin.Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.[3]

GlyCAM-1 is expressed exclusively on high endothelial venules. It is unclear how GlyCAM-1 is attached to the membrane as it lacks a transmembrane region.

Notes and References

  1. Book: Leukocyte Migration and Adhesion. 58. Imhof. Beat A.. Dunon. Dominique. 345–416. 10.1016/s0065-2776(08)60623-9. Advances in Immunology. 1995. 7537936. 9780120224586. registration.
  2. Kraal. G.. Mebius. R. E.. Watson. S. R.. 1 November 1992. Identification of a soluble form of a ligand for the lymphocyte homing receptor. 2119429. The Journal of Experimental Medicine. 176. 5. 1415–1419. 1383387. 10.1084/jem.176.5.1415. Brustein. M..
  3. Dowbenko D, Kikuta A, Fennie C, Gillett N, Lasky LA . Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk . The Journal of Clinical Investigation . 92 . 2 . 952–60 . August 1993 . 8349827 . 294935 . 10.1172/JCI116671 .

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