SLC2A11 explained
Solute carrier family 2, facilitated glucose transporter member 11 (SLC2A11) also known as glucose transporter type 10/11 (GLUT-10/11) is a protein that in humans is encoded by the SLC2A11 gene.[1]
SLC2A11 belongs to a family of plasma membrane proteins that mediate transport of sugars across the membrane by facilitative diffusion.[1] [2]
Further reading
- Doege H, Bocianski A, Scheepers A, Axer H, Eckel J, Joost HG, Schürmann A . Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle . The Biochemical Journal . 359 . Pt 2 . 443–9 . October 2001 . 11583593 . 1222165 . 10.1042/0264-6021:3590443 .
- Wu X, Li W, Sharma V, Godzik A, Freeze HH . Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues . Molecular Genetics and Metabolism . 76 . 1 . 37–45 . May 2002 . 12175779 . 10.1016/s1096-7192(02)00018-5 .
- Scheepers A, Schmidt S, Manolescu A, Cheeseman CI, Bell A, Zahn C, Joost HG, Schürmann A . Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue . Molecular Membrane Biology . 22 . 4 . 339–51 . 2005 . 16154905 . 10.1080/09687860500166143 . 40473467 .
- Manolescu AR, Augustin R, Moley K, Cheeseman C . A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity . Molecular Membrane Biology . 24 . 5–6 . 455–63 . 2007 . 17710649 . 10.1080/09687680701298143 . 35331716 . free .
Notes and References
- Web site: Entrez Gene: Solute carrier family 2 (facilitated glucose transporter), member 11.
- Sasaki T, Minoshima S, Shiohama A, Shintani A, Shimizu A, Asakawa S, Kawasaki K, Shimizu N . Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants . Biochemical and Biophysical Research Communications . 289 . 5 . 1218–24 . December 2001 . 11741323 . 10.1006/bbrc.2001.6101 .
