SLC2A10 explained

Solute carrier family 2, facilitated glucose transporter member 10 is a protein that in humans is encoded by the SLC2A10 gene.^{[1] [2]}

SLC2A10 is a member of the facilitative glucose transporter family, which plays a significant role in maintaining glucose homeostasis.[supplied by OMIM]

See also

• Glucose transporter
• Solute carrier family
• Arterial tortuosity syndrome

Further reading

• Dawson PA, Mychaleckyj JC, Fossey SC, etal . Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1 . Mol. Genet. Metab. . 74 . 1–2 . 186–99 . 2001 . 11592815 . 10.1006/mgme.2001.3212 .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Richardson S, Neama G, Phillips T, etal . Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation . Osteoarthr. Cartil. . 11 . 2 . 92–101 . 2003 . 12554125 . 10.1053/joca.2002.0858 . free .
• Wood IS, Hunter L, Trayhurn P . Expression of Class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues . Biochem. Biophys. Res. Commun. . 308 . 1 . 43–9 . 2003 . 12890477 . 10.1016/S0006-291X(03)01322-6 .
• Andersen G, Rose CS, Hamid YH, etal . Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits . Diabetes . 52 . 9 . 2445–8 . 2003 . 12941788 . 10.2337/diabetes.52.9.2445 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Zaidi SH, Peltekova V, Meyer S, etal . A family exhibiting arterial tortuosity syndrome displays homozygosity for markers in the arterial tortuosity locus at chromosome 20q13 . Clin. Genet. . 67 . 2 . 183–8 . 2005 . 15679832 . 10.1111/j.1399-0004.2004.00391.x . 21973630 .
• Mohlke KL, Skol AD, Scott LJ . Karen Mohlke . Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns . Mol. Genet. Metab. . 85 . 4 . 323–7 . 2005 . 15936967 . 10.1016/j.ymgme.2005.04.011 . etal.
• Segade F, Allred DC, Bowden DW . Functional characterization of the promoter of the human glucose transporter 10 gene . Biochim. Biophys. Acta . 1730 . 2 . 147–58 . 2005 . 16051383 . 10.1016/j.bbaexp.2005.06.012 .
• Coucke PJ, Willaert A, Wessels MW, etal . Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome . Nat. Genet. . 38 . 4 . 452–7 . 2006 . 16550171 . 10.1038/ng1764 . 11379/29243 . 836017 . free .
• Lin WH, Chuang LM, Chen CH, etal . Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population . Diabetologia . 49 . 6 . 1214–21 . 2006 . 16586067 . 10.1007/s00125-006-0218-3 . free .

Notes and References

1. McVie-Wylie AJ, Lamson DR, Chen YT . Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility . Genomics . 72 . 1 . 113–7 . Mar 2001 . 11247674 . 10.1006/geno.2000.6457 .
2. Web site: Entrez Gene: SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10.