GLTP explained

Glycolipid transfer protein is a protein that in humans is encoded by the GLTP gene.^{[1] [2] [3]}

The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein.^[4]

Further reading

• Brown RE, Mattjus P . Glycolipid transfer proteins. . Biochim. Biophys. Acta . 1771 . 6 . 746–60 . 2007 . 17320476 . 10.1016/j.bbalip.2007.01.011 . 1986823 .
• Abe A . Primary structure of glycolipid transfer protein from pig brain. . J. Biol. Chem. . 265 . 17 . 9634–7 . 1990 . 10.1016/S0021-9258(19)38716-2 . 2190982 . free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Mattjus P, Pike HM, Molotkovsky JG, Brown RE . Charged membrane surfaces impede the protein-mediated transfer of glycosphingolipids between phospholipid bilayers. . Biochemistry . 39 . 5 . 1067–75 . 2000 . 10653652 . 10.1021/bi991810u . 2637181 .
• Lin X, Mattjus P, Pike HM . Cloning and expression of glycolipid transfer protein from bovine and porcine brain. . J. Biol. Chem. . 275 . 7 . 5104–10 . 2000 . 10671554 . 10.1074/jbc.275.7.5104 . 2621014 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Malinina L, Malakhova ML, Teplov A . Structural basis for glycosphingolipid transfer specificity. . Nature . 430 . 7003 . 1048–53 . 2004 . 15329726 . 10.1038/nature02856 . 2640488 . 2004Natur.430.1048M . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rao CS, Lin X, Pike HM . Glycolipid transfer protein mediated transfer of glycosphingolipids between membranes: a model for action based on kinetic and thermodynamic analyses. . Biochemistry . 43 . 43 . 13805–15 . 2004 . 15504043 . 10.1021/bi0492197 . 2596630 . etal.
• Rao CS, Chung T, Pike HM, Brown RE . Glycolipid transfer protein interaction with bilayer vesicles: modulation by changing lipid composition. . Biophys. J. . 89 . 6 . 4017–28 . 2006 . 16169991 . 10.1529/biophysj.105.070631 . 1366967 .
• Malinina L, Malakhova ML, Kanack AT . The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure. . PLOS Biol. . 4 . 11 . e362 . 2006 . 17105344 . 10.1371/journal.pbio.0040362 . 1618416 . etal . free .

Notes and References

1. Li XM, Malakhova ML, Lin X, Pike HM, Chung T, Molotkovsky JG, Brown RE . Human glycolipid transfer protein: probing conformation using fluorescence spectroscopy . Biochemistry . 43 . 31 . 10285–94 . Aug 2004 . 15287756 . 2593833 . 10.1021/bi0495432 .
2. Malakhova ML, Malinina L, Pike HM, Kanack AT, Patel DJ, Brown RE . Point mutational analysis of the liganding site in human glycolipid transfer protein. Functionality of the complex . J Biol Chem . 280 . 28 . 26312–20 . Jul 2005 . 15901739 . 1393170 . 10.1074/jbc.M500481200 . free .
3. Web site: Entrez Gene: GLTP glycolipid transfer protein.
4. Web site: Entrez Gene: GLTP glycolipid transfer protein.