GLRB explained

Glycine receptor subunit beta is a protein that in humans is encoded by the GLRB gene.^{[1] [2] [3]}

The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha (GLRA1, MIM 138491; GLRA2, MIM 305990) and beta subunits.[supplied by OMIM]

See also

• Glycine receptor

Further reading

• Meyer G, Kirsch J, Betz H, Langosch D . Identification of a gephyrin binding motif on the glycine receptor beta subunit . Neuron . 15 . 3 . 563–72 . 1995 . 7546736 . 10.1016/0896-6273(95)90145-0 . 10164739 . free .
• Sarang SS, Miller GW, Grant DF, Schnellmann RG . Expression and localization of the neuronal glycine receptor beta-subunit in human, rabbit and rat kidneys . Nephron . 82 . 3 . 254–60 . 1999 . 10395998 . 10.1159/000045410 . 382638 .
• Rees MI, Lewis TM, Kwok JB . Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB) . Hum. Mol. Genet. . 11 . 7 . 853–60 . 2002 . 11929858 . 10.1093/hmg/11.7.853 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. free . 2002PNAS...9916899M .
• Chen Z, Dillon GH, Huang R . Molecular determinants of proton modulation of glycine receptors . J. Biol. Chem. . 279 . 2 . 876–83 . 2004 . 14563849 . 10.1074/jbc.M307684200 . free .
• Burzomato V, Groot-Kormelink PJ, Sivilotti LG, Beato M . Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation . Recept. Channels . 9 . 6 . 353–61 . 2004 . 14698963 . 10.3109/714041016.
• Harvey K, Duguid IC, Alldred MJ . The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering . J. Neurosci. . 24 . 25 . 5816–26 . 2004 . 15215304 . 10.1523/JNEUROSCI.1184-04.2004 . 6729214 . etal.
• Grudzinska J, Schemm R, Haeger S . The beta subunit determines the ligand binding properties of synaptic glycine receptors . Neuron . 45 . 5 . 727–39 . 2005 . 15748848 . 10.1016/j.neuron.2005.01.028 . 2778607 . etal. free .

Notes and References

1. Milani N, Mulhardt C, Weber RG, Lichter P, Kioschis P, Poustka A, Becker CM . The human glycine receptor beta subunit gene (GLRB): structure, refined chromosomal localization, and population polymorphism . Genomics . 50 . 3 . 341–5 . Oct 1998 . 9676428 . 10.1006/geno.1998.5324 .
2. Handford CA, Lynch JW, Baker E, Webb GC, Ford JH, Sutherland GR, Schofield PR . Grant Robert Sutherland . The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes . Brain Res Mol Brain Res . 35 . 1–2 . 211–9 . Oct 1996 . 8717357 . 10.1016/0169-328x(95)00218-h.
3. Web site: Entrez Gene: GLRB glycine receptor, beta.