GLCE explained

D-glucuronyl C5-epimerase is an enzyme that in humans is encoded by the GLCE gene.^{[1] [2]}

Further reading

• Grigorieva E . Decreased expression of human D-glucuronyl C5-epimerase in breast cancer . Int. J. Cancer . 122 . 5 . 1172–6 . 2008 . 17985344 . 10.1002/ijc.23203 . vanc. Eshchenko T . Rykova VI . 3 . Chernakov . Alexei . Zabarovsky . Eugene . Sidorov . Sergei V. . free.
• Hagner-McWhirter A, Li JP, Oscarson S, Lindahl U . Irreversible glucuronyl C5-epimerization in the biosynthesis of heparan sulfate . J. Biol. Chem. . 279 . 15 . 14631–8 . 2004 . 14718527 . 10.1074/jbc.M313760200 . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Crawford BE, Olson SK, Esko JD, Pinhal MA . Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase . J. Biol. Chem. . 276 . 24 . 21538–43 . 2001 . 11279150 . 10.1074/jbc.M100880200 . free .
• Li JP . Characterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate . J. Biol. Chem. . 276 . 23 . 20069–77 . 2001 . 11274177 . 10.1074/jbc.M011783200 . vanc. Gong F . El Darwish K . 3 . Jalkanen . M . Lindahl . U . free .
• Nagase T . Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 5 . 6 . 355–64 . 1999 . 10048485 . 10.1093/dnares/5.6.355 . vanc. Ishikawa K . Suyama M . 3 . Kikuno . R . Hirosawa . M . Miyajima . N . Tanaka . A . Kotani . H . Nomura . N . free .
• Hillier LD . Generation and analysis of 280,000 human expressed sequence tags . Genome Res. . 6 . 9 . 807–28 . 1997 . 8889549 . 10.1101/gr.6.9.807 . vanc. Lennon G . Becker M . 3 . Bonaldo . M F . Chiapelli . B . Chissoe . S . Dietrich . N . Dubuque . T . Favello . A . free .

Notes and References

1. Ghiselli G, Agrawal A . The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the β-catenin–TCF4 pathway . Biochem J . 390 . Pt 2 . 493–9 . Aug 2005 . 15853773 . 1198929 . 10.1042/BJ20050152 .
2. Web site: Entrez Gene: GLCE glucuronic acid epimerase.