GJD3 explained
Gap junction delta-2 (GJD2), also known as connexin-36 (Cx36) or gap junction alpha-9 (GJA9), is a protein that in humans is encoded by the GJD2 gene.[1]
Function
This gene is a member of the large family of connexins that are required for the formation of gap junctions. Six connexin monomers form a hemichannel, or connexon, on the cell surface. This connexon can interact with a connexon from a neighboring cell, thus forming a channel linking the cytoplasm of the 2 cells.[1]
Further reading
- White TW, Srinivas M, Ripps H . Virtual cloning, functional expression, and gating analysis of human connexin31.9. . Am. J. Physiol., Cell Physiol. . 283 . 3 . C960–70 . 2002 . 12176752 . 10.1152/ajpcell.00163.2002 . etal.
- Gemel J, Lin X, Collins R . Cx30.2 can form heteromeric gap junction channels with other cardiac connexins. . Biochem. Biophys. Res. Commun. . 369 . 2 . 388–94 . 2008 . 18291099 . 10.1016/j.bbrc.2008.02.040 . 2323682. etal.
- Belluardo N, White TW, Srinivas M . Identification and functional expression of HCx31.9, a novel gap junction gene. . Cell Commun. Adhes. . 8 . 4–6 . 173–8 . 2001 . 12064584 . 10.3109/15419060109080719. 13136344 . etal.
- Bukauskas FF, Kreuzberg MM, Rackauskas M . Properties of mouse connexin 30.2 and human connexin 31.9 hemichannels: implications for atrioventricular conduction in the heart. . Proc. Natl. Acad. Sci. U.S.A. . 103 . 25 . 9726–31 . 2006 . 16772377 . 10.1073/pnas.0603372103 . 1480474. 2006PNAS..103.9726B . etal. free .
- Söhl G, Nielsen PA, Eiberger J, Willecke K . Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues. . Cell Commun. Adhes. . 10 . 1 . 27–36 . 2003. 12881038 . 10.1080/15419060302063. 225894 .
- Kreuzberg MM, Liebermann M, Segschneider S . Human connexin31.9, unlike its orthologous protein connexin30.2 in the mouse, is not detectable in the human cardiac conduction system. . J. Mol. Cell. Cardiol. . 46 . 4 . 553–9 . 2009 . 19168070 . 10.1016/j.yjmcc.2008.12.007 . etal.
- Unsworth HC, Aasen T, McElwaine S, Kelsell DP . Tissue-specific effects of wild-type and mutant connexin 31: a role in neurite outgrowth. . Hum. Mol. Genet. . 16 . 2 . 165–72 . 2007 . 17142249 . 10.1093/hmg/ddl452 . free .
- Nielsen PA, Beahm DL, Giepmans BN . Molecular cloning, functional expression, and tissue distribution of a novel human gap junction-forming protein, connexin-31.9. Interaction with zona occludens protein-1. . J. Biol. Chem. . 277 . 41 . 38272–83 . 2002 . 12154091 . 10.1074/jbc.M205348200 . etal. free .
Notes and References
- Web site: Entrez Gene: gap junction protein.
