GINS2 explained

DNA replication complex GINS protein PSF2 is a protein that in humans is encoded by the GINS2 gene.^{[1] [2] [3]}

Interactions

GINS2 has been shown to interact with CHEK2.^[4]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Takayama Y, Kamimura Y, Okawa M, Muramatsu S, Sugino A, Araki H . GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast . Genes Dev. . 17 . 9 . 1153–65 . 2003 . 12730134 . 196052 . 10.1101/gad.1065903 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ . ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage . Science . 316 . 5828 . 1160–6 . 2007 . 17525332 . 10.1126/science.1140321 . 2007Sci...316.1160M . 16648052 .

Notes and References

1. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Res. . 10 . 10 . 1546–60 . Nov 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
2. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics . Genome Res. . 10 . 5 . 703–13 . Aug 2000 . 10810093 . 310876 . 10.1101/gr.10.5.703 .
3. Web site: Entrez Gene: GINS2 GINS complex subunit 2 (Psf2 homolog).
4. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ . ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage . Science . 316 . 5828 . 1160–6 . May 2007 . 17525332 . 10.1126/science.1140321 . 2007Sci...316.1160M . 16648052 .