Gamma-glutamyltransferase 7 explained

Gamma-glutamyltransferase 7 is an enzyme that in humans is encoded by the GGT7 gene.^{[1] [2] [3]}

Function

Gamma-glutamyltransferase is a membrane-associated protein involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene is similar in sequence to gamma-glutamyltransferase, but its function is unknown.

Further reading

• Jikuya H, Takano J, Kikuno R, Hirosawa M, Nagase T, Nomura N, Ohara O . Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones . DNA Research . 10 . 1 . 49–57 . February 2003 . 12693554 . 10.1093/dnares/10.1.49 . free .
• Llamazares M, Cal S, Quesada V, López-Otín C . Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain . The Journal of Biological Chemistry . 278 . 15 . 13382–9 . April 2003 . 12562771 . 10.1074/jbc.M211900200 . free . 6066313 .
• He X, Di Y, Li J, Xie Y, Tang Y, Zhang F, Wei L, Zhang Y, Qin W, Huo K, Li Y, Wan D, Gu J . Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism . Biochemical and Biophysical Research Communications . 297 . 3 . 528–36 . September 2002 . 12270127 . 10.1016/S0006-291X(02)02227-1 .

Notes and References

1. Figlewicz DA, Delattre O, Guellaen G, Krizus A, Thomas G, Zucman J, Rouleau GA . Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes . Genomics . 17 . 2 . 299–305 . August 1993 . 8104871 . 10.1006/geno.1993.1325 .
2. Heisterkamp N, Groffen J, Warburton D, Sneddon TP . The human gamma-glutamyltransferase gene family . Human Genetics . 123 . 4 . 321–32 . May 2008 . 18357469 . 10.1007/s00439-008-0487-7 . 15916758 .
3. Web site: Entrez Gene: GGTL3 gamma-glutamyltransferase-like 3.