GFI1B explained

Zinc finger protein Gfi-1b is a protein that in humans is encoded by the GFI1B gene.^{[1] [2]}

Further reading

• Tong B, Grimes HL, Yang TY . The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation. . Mol. Cell. Biol. . 18 . 5 . 2462–73 . 1998 . 9566867 . 10.1128/mcb.18.5.2462. 110626 . etal.
• Osawa M, Yamaguchi T, Nakamura Y . Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis. . Blood . 100 . 8 . 2769–77 . 2002 . 12351384 . 10.1182/blood-2002-01-0182 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Huang DY, Kuo YY, Lai JS . GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene. . Nucleic Acids Res. . 32 . 13 . 3935–46 . 2004 . 15280509 . 10.1093/nar/gkh719 . 506805 . etal.
• Garçon L, Lacout C, Svinartchouk F . Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells. . Blood . 105 . 4 . 1448–55 . 2005 . 15507521 . 10.1182/blood-2003-11-4068 . etal. free .
• Huang DY, Kuo YY, Chang ZF . GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells. . Nucleic Acids Res. . 33 . 16 . 5331–42 . 2005 . 16177182 . 10.1093/nar/gki838 . 1226314 .
• Lim J, Hao T, Shaw C . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . etal. free .
• Xu W, Kee BL . Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas. . Blood . 109 . 10 . 4406–14 . 2007 . 17272506 . 10.1182/blood-2006-08-043331 . free .
• Kuo YY, Chang ZF . GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription. . Mol. Cell. Biol. . 27 . 12 . 4261–72 . 2007 . 17420275 . 10.1128/MCB.02212-06 . 1900040 .

Notes and References

1. Rodel B, Wagner T, Zornig M, Niessing J, Moroy T . The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases . Genomics . 54 . 3 . 580–2 . Feb 1999 . 9878267 . 10.1006/geno.1998.5601 .
2. Web site: Entrez Gene: GFI1B growth factor independent 1B (potential regulator of CDKN1A, translocated in CML).