GEMIN8 explained

Gem-associated protein 8 (Gemin-8) is a protein that in humans is encoded by the GEMIN8 gene.^{[1] [2]}

Function

Gemin-8 is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. Gemin-8 binds to both SMN1 and the GEMIN6 / GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.^[1]

Further reading

• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Carissimi C, Saieva L, Gabanella F, Pellizzoni L . Gemin8 is required for the architecture and function of the survival motor neuron complex. . J. Biol. Chem. . 281 . 48 . 37009–16 . 2006 . 17023415 . 10.1074/jbc.M607505200 . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928. etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .

Notes and References

1. Web site: Entrez Gene: gem (nuclear organelle) associated protein 8.
2. Carissimi C, Saieva L, Baccon J, Chiarella P, Maiolica A, Sawyer A, Rappsilber J, Pellizzoni L . Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly . J. Biol. Chem. . 281 . 12 . 8126–34 . March 2006 . 16434402 . 10.1074/jbc.M512243200 . free .