GEFT explained

RAC/CDC42 exchange factor, also known as GEFT, is a human gene.^[1]

Interactions

GEFT has been shown to interact with RHOA.^[2]

Further reading

• Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ . Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. . Science . 318 . 5858 . 1923–7 . 2008 . 18096806 . 10.1126/science.1147554 . 2418867 .
• Bryan BA, Cai Y, Liu M . The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth. . J. Neurosci. Res. . 83 . 7 . 1151–9 . 2006 . 16496360 . 10.1002/jnr.20814 . 11130365 .
• Bryan BA, Mitchell DC, Zhao L, Ma W, Stafford LJ, Teng BB, Liu M . Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT. . Mol. Cell. Biol. . 25 . 24 . 11089–101 . 2006 . 16314529 . 1316953 . 10.1128/MCB.25.24.11089-11101.2005 .
• Lutz S, Freichel-Blomquist A, Yang Y, Rümenapp U, Jakobs KH, Schmidt M, Wieland T . The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA. . J. Biol. Chem. . 280 . 12 . 11134–9 . 2005 . 15632174 . 10.1074/jbc.M411322200 . free .
• Bryan B, Kumar V, Stafford LJ, Cai Y, Wu G, Liu M . GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation. . J. Biol. Chem. . 279 . 44 . 45824–32 . 2004 . 15322108 . 10.1074/jbc.M406216200 . free .
• Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T . p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene. . Naunyn-Schmiedeberg's Arch. Pharmacol. . 369 . 5 . 540–6 . 2004 . 15069594 . 10.1007/s00210-004-0926-5 . 19812449 .
• Guo X, Stafford LJ, Bryan B, Xia C, Ma W, Wu X, Liu D, Songyang Z, Liu M . A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration. . J. Biol. Chem. . 278 . 15 . 13207–15 . 2003 . 12547822 . 10.1074/jbc.M208896200 . free .
• Souchet M, Portales-Casamar E, Mazurais D, Schmidt S, Léger I, Javré JL, Robert P, Berrebi-Bertrand I, Bril A, Gout B, Debant A, Calmels TP . Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere. . J. Cell Sci. . 115 . Pt 3 . 629–40 . 2002 . 10.1242/jcs.115.3.629 . 11861769 .

Notes and References

1. Web site: Entrez Gene: GEFT RAC/CDC42 exchange factor.
2. Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T . p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene . Naunyn-Schmiedeberg's Arch. Pharmacol. . 369 . 5 . 540–6 . May 2004 . 15069594 . 10.1007/s00210-004-0926-5 . 19812449 .