Guanosine diphosphate mannose explained

Guanosine diphosphate mannose or GDP-mannose is a nucleotide sugar that is a substrate for glycosyltransferase reactions in metabolism. This compound is a substrate for enzymes called mannosyltransferases.

Known as donor of activated mannose in all glycolytic reactions, GDP-mannose is essential in eukaryotes.[1]

Biosynthesis

GDP-mannose is produced from GTP and mannose-6-phosphate by the enzyme mannose-1-phosphate guanylyltransferase (GDP-mannose pyrophosphorylase, GDP-MP).[2] This enzyme belongs to a family of nucleotidyl-transferases and is a pervasive enzyme found in bacteria, fungi, plants, and animals.[3]

See also

Notes and References

  1. Stewart. James. Curtis. Joan. Spurck. Timothy P.. Ilg. Thomas. Garami. Attila. Baldwin. Tracey. Courret. Nathalie. McFadden. Geoffrey I.. Davis. Antony. Handman. Emanuela. July 2005 . Characterisation of a Leishmania mexicana knockout lacking guanosine diphosphate-mannose pyrophosphorylase. International Journal for Parasitology. en. 35. 8. 861–873. 10.1016/j.ijpara.2005.03.008. 15936761.
  2. Samuel G, Reeves P . Biosynthesis of O-antigens: genes and pathways involved in nucleotide sugar precursor synthesis and O-antigen assembly . Carbohydrate Research . 338 . 23 . 2503–19 . 2003 . 14670712 . 10.1016/j.carres.2003.07.009.
  3. Pomel. Sébastien. Mao. Wei. Ha-Duong. Tâp. Cavé. Christian. Loiseau. Philippe M.. 2019-05-31. GDP-Mannose Pyrophosphorylase: A Biologically Validated Target for Drug Development Against Leishmaniasis. Frontiers in Cellular and Infection Microbiology. 9. 186. 10.3389/fcimb.2019.00186. 2235-2988. 6554559. 31214516. free.

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