GDP-4-dehydro-D-rhamnose reductase explained

GDP-4-dehydro-D-rhamnose reductase
Ec Number:	1.1.1.187
Cas Number:	9075-56-3
Go Code:	0042356

In enzymology, a GDP-4-dehydro-D-rhamnose reductase is an enzyme that catalyzes the chemical reaction

GDP-6-deoxy-D-mannose + NAD(P)⁺

\rightleftharpoons GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H⁺

The 3 substrates of this enzyme are GDP-6-deoxy-D-mannose, NAD⁺, and NADP⁺, whereas its 4 products are GDP-4-dehydro-6-deoxy-D-mannose, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is GDP-6-deoxy-D-mannose:NAD(P)⁺ 4-oxidoreductase. Other names in common use include GDP-4-keto-6-deoxy-D-mannose reductase, GDP-4-keto-D-rhamnose reductase, and guanosine diphosphate-4-keto-D-rhamnose reductase. This enzyme participates in fructose and mannose metabolism.

References

• Barber GA . 1968 . The synthesis of guanosine 5'-diphosphate D-rhamnose by enzymes of a higher plant . Biochim. Biophys. Acta . 165 . 68 - 75 . 4386238 . 1 . 10.1016/0304-4165(68)90189-x.
• Winkler NW, Markovitz A . 1971 . Guanosine diphosphate-4-keto-D-rhamnose reductase. A non-stereoselective enzyme . J. Biol. Chem. . 246 . 5868 - 76 . 4398966 . 19 .