GCS1 explained

Mannosyl-oligosaccharide glucosidase is an enzyme that in humans is encoded by the MOGS gene.^{[1] [2] [3]}

Glucosidase I is the first enzyme in the N-linked oligosaccharide processing pathway. GCS1 cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. GCS1 is located in the lumen of the endoplasmic reticulum.

GCS1 may also refer to "generative cell specific 1", also called HAP2 (hapless2), a gene of lower eukaryotes which is thought to be responsible for gametes fusion .^[4] .

Further reading

• Feizi T, Larkin M . AIDS and glycosylation . Glycobiology . 1 . 1 . 17–23 . 1992 . 2136376 . 10.1093/glycob/1.1.17 .
• Land A, Braakman I . Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum . Biochimie . 83 . 8 . 783–90 . 2001 . 11530211 . 10.1016/S0300-9084(01)01314-1 . 1874/5091 . 13576808 . free .
• Fenouillet E, Gluckman JC . Effect of a glucosidase inhibitor on the bioactivity and immunoreactivity of human immunodeficiency virus type 1 envelope glycoprotein . J. Gen. Virol. . 72 . 8. 1919–26 . 1991 . 1678778 . 10.1099/0022-1317-72-8-1919 . free .
• Ratner L, vander Heyden N, Dedera D . Inhibition of HIV and SIV infectivity by blockade of alpha-glucosidase activity . Virology . 181 . 1 . 180–92 . 1991 . 1704656 . 10.1016/0042-6822(91)90483-R .
• Dedera DA, Gu RL, Ratner L . Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function . Virology . 187 . 1 . 377–82 . 1992 . 1736542 . 10.1016/0042-6822(92)90331-I .
• Murphy CI, Lennick M, Lehar SM . Temporal expression of HIV-1 envelope proteins in baculovirus-infected insect cells: implications for glycosylation and CD4 binding . Genet. Anal. Tech. Appl. . 7 . 6 . 160–71 . 1991 . 2076345 . 10.1016/0735-0651(90)90030-J . etal.
• Kalyanaraman VS, Rodriguez V, Veronese F . Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1 . AIDS Res. Hum. Retroviruses . 6 . 3 . 371–80 . 1990 . 2187500 . 10.1089/aid.1990.6.371 . etal.
• Shimizu H, Tsuchie H, Honma H . Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins . Jpn. J. Med. Sci. Biol. . 43 . 3 . 75–87 . 1991 . 2283726 . 10.7883/yoken1952.43.75. etal. free .
• Leonard CK, Spellman MW, Riddle L . Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells . J. Biol. Chem. . 265 . 18 . 10373–82 . 1990 . 10.1016/S0021-9258(18)86956-3 . 2355006 . etal. free .
• Pal R, Hoke GM, Sarngadharan MG . Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1 . Proc. Natl. Acad. Sci. U.S.A. . 86 . 9 . 3384–8 . 1989 . 2541446 . 10.1073/pnas.86.9.3384 . 287137 . 1989PNAS...86.3384P . free .
• Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP . Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport . J. Virol. . 63 . 6 . 2452–6 . 1989 . 2542563 . 10.1128/jvi.63.6.2452-2456.1989. 250699 .
• Kozarsky K, Penman M, Basiripour L . Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein . J. Acquir. Immune Defic. Syndr. . 2 . 2 . 163–9 . 1989 . 2649653 . etal.
• Walker BD, Kowalski M, Goh WC . Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine . Proc. Natl. Acad. Sci. U.S.A. . 84 . 22 . 8120–4 . 1987 . 2825177 . 10.1073/pnas.84.22.8120 . 299490 . etal. 1987PNAS...84.8120W . free .
• Robinson WE, Montefiori DC, Mitchell WM . Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis . AIDS Res. Hum. Retroviruses . 3 . 3 . 265–82 . 1988 . 2829950 . 10.1089/aid.1987.3.265 .
• Gruters RA, Neefjes JJ, Tersmette M . Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase . Nature . 330 . 6143 . 74–7 . 1987 . 2959866 . 10.1038/330074a0 . etal. 1987Natur.330...74G . 4270139 .
• Blough HA, Pauwels R, De Clercq E . Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins . Biochem. Biophys. Res. Commun. . 141 . 1 . 33–8 . 1987 . 3099781 . 10.1016/S0006-291X(86)80330-8 . etal.
• Montefiori DC, Robinson WE, Mitchell WM . Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1 . Proc. Natl. Acad. Sci. U.S.A. . 85 . 23 . 9248–52 . 1988 . 3264072 . 10.1073/pnas.85.23.9248 . 282716 . 1988PNAS...85.9248M . free .
• Fenouillet E, Jones I, Powell B . Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain . J. Virol. . 67 . 1 . 150–60 . 1993 . 8093218 . 10.1128/jvi.67.1.150-160.1993. 237347 . etal.

External links

• GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview

Notes and References

1. Kalz-Fuller B, Bieberich E, Bause E . Sexualization and expression of glucosidase I from human hippocampus . Eur J Biochem . 231 . 2 . 344–51 . Sep 1995 . 7635146 . 10.1111/j.1432-1033.1995.tb20706.x .
2. Kalz-Fuller B, Heidrich-Kaul C, Nothen M, Bause E, Schwanitz G . Localization of the human glucosidase I gene to chromosome 2p12-p13 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids . Genomics . 34 . 3 . 442–3 . Sep 1996 . 8786151 . 10.1006/geno.1996.0313 .
3. Web site: Entrez Gene: GCS1 glucosidase I.
4. Gamete Fusion: Key Protein Identified . 10.1016/j.cub.2008.05.007 . 18 . 13 . 2008 . Current Biology . R571–R573 . Goodman CD, McFadden GI. 18606131. 14367758. free . 2008CBio...18.R571G .