KAT2A explained

Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the KAT2A gene.^{[1] [2]}

Interactions

GCN5L2 has been shown to interact with:

• DDB1,
• Ku70,^[3]
• Ku80,^[3]
• TADA2L,^{[3] [4]}
• TAF9,^[5] and
• Transcription initiation protein SPT3 homolog.^{[5] [6]}

Further reading

• Berry R, Stevens TJ, Walter NA, Wilcox AS, Rubano T, Hopkins JA, Weber J, Goold R, Soares MB, Sikela JM . Gene-based sequence-tagged-sites (STSs) as the basis for a human gene map. . Nat. Genet. . 10 . 4 . 415–23 . 1995 . 7670491 . 10.1038/ng0895-415 . 22277955 .
• Yang XJ, Ogryzko VV, Nishikawa J, Howard BH, Nakatani Y . A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. . Nature . 382 . 6589 . 319–24 . 1996 . 8684459 . 10.1038/382319a0 . 1996Natur.382..319Y . 4328685 .
• Wang L, Mizzen C, Ying C, Candau R, Barlev N, Brownell J, Allis CD, Berger SL . Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation. . Mol. Cell. Biol. . 17 . 1 . 519–27 . 1997 . 8972232 . 231776 . 10.1128/mcb.17.1.519.
• Carter KC, Wang L, Shell BK, Zamir I, Berger SL, Moore PA . The human transcriptional adaptor genes TADA2L and GCN5L2 colocalize to chromosome 17q12-q21 and display a similar tissue expression pattern. . Genomics . 40 . 3 . 497–500 . 1997 . 9073520 . 10.1006/geno.1996.4605 .
• Barlev NA, Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman JL, Berger SL . Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex. . Mol. Cell. Biol. . 18 . 3 . 1349–58 . 1998 . 9488450 . 108848 . 10.1128/mcb.18.3.1349.
• Smith ER, Belote JM, Schiltz RL, Yang XJ, Moore PA, Berger SL, Nakatani Y, Allis CD . Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. . Nucleic Acids Res. . 26 . 12 . 2948–54 . 1998 . 9611240 . 147644 . 10.1093/nar/26.12.2948 .
• Randhawa GS, Bell DW, Testa JR, Feinberg AP . Identification and mapping of human histone acetylation modifier gene homologues. . Genomics . 51 . 2 . 262–9 . 1998 . 9722949 . 10.1006/geno.1998.5370 . free .
• Xu W, Edmondson DG, Roth SY . Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. . Mol. Cell. Biol. . 18 . 10 . 5659–69 . 1998 . 9742083 . 109152 . 10.1128/MCB.18.10.5659.
• Brand M, Yamamoto K, Staub A, Tora L . Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. . J. Biol. Chem. . 274 . 26 . 18285–9 . 1999 . 10373431 . 10.1074/jbc.274.26.18285 . free .
• McMahon SB, Wood MA, Cole MD . The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. . Mol. Cell. Biol. . 20 . 2 . 556–62 . 2000 . 10611234 . 85131 . 10.1128/MCB.20.2.556-562.2000 .
• Kurooka H, Honjo T . Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. . J. Biol. Chem. . 275 . 22 . 17211–20 . 2000 . 10747963 . 10.1074/jbc.M000909200 . free .
• Hudson BP, Martinez-Yamout MA, Dyson HJ, Wright PE. Jane Dyson . Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain. . J. Mol. Biol. . 304 . 3 . 355–70 . 2000 . 11090279 . 10.1006/jmbi.2000.4207 .
• Col E, Caron C, Seigneurin-Berny D, Gracia J, Favier A, Khochbin S . The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. . J. Biol. Chem. . 276 . 30 . 28179–84 . 2001 . 11384967 . 10.1074/jbc.M101385200 . free .
• Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L . UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. . EMBO J. . 20 . 12 . 3187–96 . 2001 . 11406595 . 150203 . 10.1093/emboj/20.12.3187 .
• Gangloff YG, Pointud JC, Thuault S, Carré L, Romier C, Muratoglu S, Brand M, Tora L, Couderc JL, Davidson I . The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger. . Mol. Cell. Biol. . 21 . 15 . 5109–21 . 2001 . 11438666 . 87236 . 10.1128/MCB.21.15.5109-5121.2001 .
• Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG . Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. . Mol. Cell. Biol. . 21 . 20 . 6782–95 . 2001 . 11564863 . 99856 . 10.1128/MCB.21.20.6782-6795.2001 .
• Brès V, Kiernan R, Emiliani S, Benkirane M . Tat acetyl-acceptor lysines are important for human immunodeficiency virus type-1 replication. . J. Biol. Chem. . 277 . 25 . 22215–21 . 2002 . 11956210 . 10.1074/jbc.M201895200 . free .
• Col E, Gilquin B, Caron C, Khochbin S . Tat-controlled protein acetylation. . J. Biol. Chem. . 277 . 40 . 37955–60 . 2002 . 12154097 . 10.1074/jbc.M206694200 . free .

Notes and References

1. Candau R, Moore PA, Wang L, Barlev N, Ying CY, Rosen CA, Berger SL . Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5 . Mol Cell Biol . 16 . 2 . 593–602 . February 1996 . 8552087 . 231038 . 10.1128/mcb.16.2.593.
2. Web site: Entrez Gene: GCN5L2 GCN5 general control of amino-acid synthesis 5-like 2 (yeast).
3. Barlev NA, Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman JL, Berger SL . Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex . Mol. Cell. Biol. . 18 . 3 . 1349–58 . March 1998 . 9488450 . 108848 . 10.1128/mcb.18.3.1349.
4. Wang L, Mizzen C, Ying C, Candau R, Barlev N, Brownell J, Allis CD, Berger SL . Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation . Mol. Cell. Biol. . 17 . 1 . 519–27 . January 1997 . 8972232 . 231776 . 10.1128/mcb.17.1.519.
5. Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG . Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo . Mol. Cell. Biol. . 21 . 20 . 6782–95 . October 2001 . 11564863 . 99856 . 10.1128/MCB.21.20.6782-6795.2001 .
6. Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L . UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation . EMBO J. . 20 . 12 . 3187–96 . June 2001 . 11406595 . 150203 . 10.1093/emboj/20.12.3187 .