GCM2 explained

Chorion-specific transcription factor GCMb is a protein that in humans is encoded by the GCM2 gene.^{[1] [2]}

The Drosophila 'glial cells missing' (gcm) gene is thought to act as a binary switch between neuronal and glial cell determination. The gcm protein and mammalian gcm homologs contain a conserved N-terminal gcm motif that has DNA-binding activity. See GCM1 (MIM 603715).[supplied by OMIM]

Further reading

• Kammerer M, Pirola B, Giglio S, Giangrande A . GCMB, a second human homolog of the fly glide/gcm gene . Cytogenet. Cell Genet. . 84 . 1–2 . 43–7 . 1999 . 10343099 . 10.1159/000015210 . 23760189 .
• Correa P, Akerström G, Westin G . Underexpression of Gcm2, a master regulatory gene of parathyroid gland development, in adenomas of primary hyperparathyroidism . Clin. Endocrinol. . 57 . 4 . 501–5 . 2002 . 12354132 . 10.1046/j.1365-2265.2002.01627.x . 2137270 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Mungall AJ, Palmer SA, Sims SK . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . etal. free .
• Maret A, Bourdeau I, Ding C . Expression of GCMB by intrathymic parathyroid hormone-secreting adenomas indicates their parathyroid cell origin . J. Clin. Endocrinol. Metab. . 89 . 1 . 8–12 . 2004 . 14715818 . 10.1210/jc.2003-030733 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Kebebew E, Peng M, Wong MG . GCMB gene, a master regulator of parathyroid gland development, expression, and regulation in hyperparathyroidism . Surgery . 136 . 6 . 1261–6 . 2005 . 15657585 . 10.1016/j.surg.2004.06.056 . etal.
• Thomée C, Schubert SW, Parma J . GCMB mutation in familial isolated hypoparathyroidism with residual secretion of parathyroid hormone . J. Clin. Endocrinol. Metab. . 90 . 5 . 2487–92 . 2005 . 15728199 . 10.1210/jc.2004-2450 . etal. free .
• Baumber L, Tufarelli C, Patel S . Identification of a novel mutation disrupting the DNA binding activity of GCM2 in autosomal recessive familial isolated hypoparathyroidism . J. Med. Genet. . 42 . 5 . 443–8 . 2006 . 15863676 . 10.1136/jmg.2004.026898 . 1736051 . etal.

Notes and References

1. Kanemura Y, Hiraga S, Arita N, Ohnishi T, Izumoto S, Mori K, Matsumura H, Yamasaki M, Fushiki S, Yoshimine T . Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene . FEBS Lett . 442 . 2–3 . 151–6 . Feb 1999 . 9928992 . 10.1016/S0014-5793(98)01650-0 . 2469563 .
2. Web site: Entrez Gene: GCM2 glial cells missing homolog 2 (Drosophila).