GCC2 explained

GRIP and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the GCC2 gene.^[1]

The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[2]

Further reading

• Derby MC, Lieu ZZ, Brown D . The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure. . Traffic . 8 . 6 . 758–73 . 2007 . 17488291 . 10.1111/j.1600-0854.2007.00563.x . 21624858 . etal. free .
• Beausoleil SA, Villén J, Gerber SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 . etal.
• Reddy JV, Burguete AS, Sridevi K . A Functional Role for the GCC185 Golgin in Mannose 6-Phosphate Receptor Recycling . Mol. Biol. Cell . 17 . 10 . 4353–63 . 2007 . 16885419 . 10.1091/mbc.E06-02-0153 . 1635343 . etal.
• Hillier LW, Graves TA, Fulton RS . Generation and annotation of the DNA sequences of human chromosomes 2 and 4 . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . etal. free .
• Luke MR, Houghton F, Perugini MA, Gleeson PA . The trans-Golgi network GRIP-domain proteins form α-helical homodimers . Biochem. J. . 388 . Pt 3 . 835–41 . 2005 . 15654769 . 10.1042/BJ20041810 . 1183463 .
• Derby MC, van Vliet C, Brown D . Mammalian GRIP domain proteins differ in their membrane binding properties and are recruited to distinct domains of the TGN . J. Cell Sci. . 117 . Pt 24 . 5865–74 . 2005 . 15522892 . 10.1242/jcs.01497 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Lu L, Hong W . Interaction of Arl1-GTP with GRIP Domains Recruits Autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi . Mol. Biol. Cell . 14 . 9 . 3767–81 . 2004 . 12972563 . 10.1091/mbc.E03-01-0864 . 196566 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Krackhardt AM, Witzens M, Harig S . Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX . Blood . 100 . 6 . 2123–31 . 2002 . 12200376 . 10.1182/blood-2002-02-0513 . etal. free .
• Eichmuller S, Usener D, Dummer R . Serological detection of cutaneous T-cell lymphoma-associated antigens . Proc. Natl. Acad. Sci. U.S.A. . 98 . 2 . 629–34 . 2001 . 11149944 . 10.1073/pnas.021386498 . 14639 . etal. free .
• Scanlan MJ, Gordan JD, Williamson B . Antigens recognized by autologous antibody in patients with renal-cell carcinoma . Int. J. Cancer . 83 . 4 . 456–64 . 1999 . 10508479 . 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 . etal. 21839750 .
• Nagase T, Ishikawa K, Nakajima D . Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res. . 4 . 2 . 141–50 . 1997 . 9205841 . 10.1093/dnares/4.2.141 . etal. free .

Notes and References

1. Luke MR, Kjer-Nielsen L, Brown DL, Stow JL, Gleeson PA . GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network . J Biol Chem . 278 . 6 . 4216–26 . Feb 2003 . 12446665 . 10.1074/jbc.M210387200 . free.
2. Web site: Entrez Gene: GCC2 GRIP and coiled-coil domain containing 2.