GCC1 explained

GRIP and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the GCC1 gene.^{[1] [2]}

Function

The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport.^[2]

Interactions

GCC1 has been shown to interact with TRIM29.^[3]

Further reading

• Luke MR, Kjer-Nielsen L, Brown DL, Stow JL, Gleeson PA . GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network . J. Biol. Chem. . 278 . 6 . 4216–26 . 2003 . 12446665 . 10.1074/jbc.M210387200 . free .
• Lu L, Hong W . Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi . Mol. Biol. Cell . 14 . 9 . 3767–81 . 2003 . 12972563 . 196566 . 10.1091/mbc.E03-01-0864 .
• Luke MR, Houghton F, Perugini MA, Gleeson PA . The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers . Biochem. J. . 388 . Pt 3 . 835–41 . 2005 . 15654769 . 1183463 . 10.1042/BJ20041810 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .

Notes and References

1. Kjer-Nielsen L, Teasdale RD, van Vliet C, Gleeson PA . A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins . Curr. Biol. . 9 . 7 . 385–8 . May 1999 . 10209125 . 10.1016/S0960-9822(99)80168-7 . 14342088 . free . 1999CBio....9..385K .
2. Web site: Entrez Gene: GCC1 GRIP and coiled-coil domain containing 1.
3. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network. Huda Zoghbi . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R. 4427026.