GBR-13098 explained

GBR-13098 is a psychostimulant and selective dopamine uptake inhibitor.^[1]

Blocking the endogenous striatal dopamine (DA) transporter with GBR-13098 in mice has been shown to prevent damage to the DA nerve terminals caused by malonate. It was suggested that DA transporter inhibitors like GBR-13098 could be used to prevent or treat neurodegenerative disorders caused by the effect of mitochondrial dysfunction on DA homeostasis.^[2]

See also

• Vanoxerine
• GBR-12783
• GBR-12935
• GBR-13069
• DBL-583

Notes and References

1. GBR 13098, a selective dopamine uptake inhibitor; behavioural, biochemical and electrophysiological studies . Pileblad E, and Engberg G. . Naunyn-Schmiedeberg's Arch Pharmacol . Dec 1986 . 334 . 4 . 383–7 . 10.1007/BF00569374 . 2950328. 4685374 .
2. Mitochondrial stress-induced dopamine efflux and neuronal damage by malonate involves the dopamine transporter . Moy LY . J Pharmacol Exp Ther . Feb 2007 . 320 . 2 . 747–56 . 10.1124/jpet.106.110791. 17090704 . 9886591 . etal.