GBGT1 explained

Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the GBGT1 gene.^{[1] [2] [3]}

This gene encodes a member of the histo-blood group ABO gene family that encodes glycosyltransferases with related but distinct substrate specificity. This protein plays a role in synthesizing Forssman glycolipid (FG), a member of the globoseries glycolipid family. Human cells do not normally produce FG but produce the precursor glycolipids globotriaosylceramide and globoside. This protein may be involved in the tropism and binding of pathogenic organisms.^[3]

Further reading

• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A . 6 . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Research . 13 . 10 . 2265–70 . October 2003 . 12975309 . 403697 . 10.1101/gr.1293003 .
• Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K . 6 . Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants . Molecular Vision . 8 . 205–20 . June 2002 . 12107410 .

Notes and References

1. Xu H, Storch T, Yu M, Elliott SP, Haslam DB . Characterization of the human Forssman synthetase gene. An evolving association between glycolipid synthesis and host-microbial interactions . The Journal of Biological Chemistry . 274 . 41 . 29390–8 . October 1999 . 10506200 . 10.1074/jbc.274.41.29390 . free.
2. Haslam DB, Baenziger JU . Expression cloning of Forssman glycolipid synthetase: a novel member of the histo-blood group ABO gene family . Proceedings of the National Academy of Sciences of the United States of America . 93 . 20 . 10697–702 . October 1996 . 8855242 . 38217 . 10.1073/pnas.93.20.10697 . 1996PNAS...9310697H . free .
3. Web site: Entrez Gene: GBGT1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1.