GATAD2B explained

Transcriptional repressor p66-beta is a protein that in humans is encoded by the GATAD2B gene.^{[1] [2] [3]}

Interactions

GATAD2B has been shown to interact with Methyl-CpG-binding domain protein 2,^[4] MBD3,^{[2] [4]} RBBP7^[2] and RBBP4.^[2]

Further reading

• Brackertz M, Boeke J, Zhang R, Renkawitz R . Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3. . J. Biol. Chem. . 277 . 43 . 40958–66 . 2002 . 12183469 . 10.1074/jbc.M207467200 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Colland F, Jacq X, Trouplin V . Functional proteomics mapping of a human signaling pathway. . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 . etal.
• Beausoleil SA, Jedrychowski M, Schwartz D . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . etal. 2004PNAS..10112130B . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Brackertz M, Gong Z, Leers J, Renkawitz R . p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction. . Nucleic Acids Res. . 34 . 2 . 397–406 . 2006 . 16415179 . 10.1093/nar/gkj437 . 1331983 .
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . etal. 2006Natur.441..315G . free .
• Beausoleil SA, Villén J, Gerber SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 . etal.

Notes and References

1. Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O . Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain . DNA Res . 6 . 5 . 329–36 . Jan 2000 . 10574461 . 10.1093/dnares/6.5.329 . free . 263221761 .
2. Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y . Identification and functional characterization of the p66/p68 components of the MeCP1 complex . Mol Cell Biol . 22 . 2 . 536–46 . Dec 2001 . 11756549 . 139742 . 10.1128/MCB.22.2.536-546.2002 .
3. Web site: Entrez Gene: GATAD2B GATA zinc finger domain containing 2B.
4. Brackertz . Marc . Boeke Joern . Zhang Ru . Renkawitz Rainer . Oct 2002 . Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3 . J. Biol. Chem. . 277 . 43 . 40958–66 . United States. 0021-9258. 12183469 . 10.1074/jbc.M207467200 . free .