GAS7 explained

Growth arrest-specific protein 7 is a protein that in humans is encoded by the GAS7 gene.^{[1] [2]}

Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described.

Further reading

• Kurtz A, Zimmer A . Interspecies fluorescence in situ hybridization further defines synteny homology between mouse chromosome 11 and human chromosome 17 . Mamm. Genome . 6 . 5 . 379–380 . 1995 . 7626897 . 10.1007/BF00364810 . 32467578 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–174 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–156 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . vanc. Yoshitomo-Nakagawa K . Maruyama K . 3 . Suyama . A . Sugano . S .
• Ishikawa K . Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 4 . 5 . 307–313 . 1998 . 9455477 . 10.1093/dnares/4.5.307 . vanc. Nagase T . Nakajima D . 3 . Seki . N . Ohira . M . Miyajima . N . Tanaka . A . Kotani . H . Nomura . N . free .
• Megonigal MD . Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors . Proc. Natl. Acad. Sci. U.S.A. . 97 . 6 . 2814–2819 . 2000 . 10706619 . 10.1073/pnas.050397097 . 16012 . vanc. Cheung NK . Rappaport EF . 3 . Nowell . PC . Wilson . RB . Jones . DH . Addya . K . Leonard . DG . Kushner . BH . 2000PNAS...97.2814M . free .
• She BR, Liou GG, Lin-Chao S . Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth . Exp. Cell Res. . 273 . 1 . 34–44 . 2002 . 11795944 . 10.1006/excr.2001.5435 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Chao CC, Chang PY, Lu HH . Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth . J. Neurosci. Res. . 81 . 2 . 153–162 . 2005 . 15948147 . 10.1002/jnr.20552 . 9789678 . free .

Notes and References

1. Ju YT, Chang AC, She BR, Tsaur ML, Hwang HM, Chao CC, Cohen SN, Lin-Chao S . gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation . Proc Natl Acad Sci U S A . 95 . 19 . 11423–11428 . Oct 1998 . 9736752 . 21658 . 10.1073/pnas.95.19.11423 . 1998PNAS...9511423J . free .
2. Web site: Entrez Gene: GAS7 growth arrest-specific 7.