GAS2L1 explained

GAS2-like protein 1 is a protein that in humans is encoded by the GAS2L1 gene.^{[1] [2] [3] [4]}

The protein encoded by this gene, a member of the GAS2 family, is similar in sequence to the mouse protein Gas2, an actin-associated protein expressed at high levels in growth-arrested cells. Expression of the mouse Gas2 gene is negatively regulated by serum and growth factors. Three transcript variants encoding two different isoforms have been found for this gene.^[5]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Weinmann AS, Yan PS, Oberley MJ . Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis . Genes Dev. . 16 . 2 . 235–44 . 2002 . 11799066 . 10.1101/gad.943102 . 155318 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . etal. free .

Notes and References

1. Zucman-Rossi J, Legoix P, Thomas G . Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region . Genomics . 38 . 3 . 247–54 . Mar 1997 . 8975699 . 10.1006/geno.1996.0625 .
2. Goriounov D, Leung CL, Liem RK . Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules . J Cell Sci . 116 . Pt 6 . 1045–58 . Feb 2003 . 12584248 . 10.1242/jcs.00272 . free .
3. Brancolini C, Bottega S, Schneider C . Gas2, a growth arrest-specific protein, is a component of the microfilament network system . J Cell Biol . 117 . 6 . 1251–61 . Jul 1992 . 1607387 . 2289493 . 10.1083/jcb.117.6.1251 .
4. Web site: Entrez Gene: GAS2L1 growth arrest-specific 2 like 1.
5. Web site: Entrez Gene: GAS2L1 growth arrest-specific 2 like 1.