GAS2 explained

Growth arrest-specific protein 2 is a protein that in humans is encoded by the GAS2 gene.^{[1] [2]}

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.

Further reading

• Olson RE, Morello JA, Kieff ED . Antibiotic treatment of oral anaerobic infections . Journal of Oral Surgery . 33 . 8 . 619–21 . 1975 . 1056466 .
• Brancolini C, Bottega S, Schneider C . Gas2, a growth arrest-specific protein, is a component of the microfilament network system . J. Cell Biol. . 117 . 6 . 1251–61 . 1992 . 1607387 . 10.1083/jcb.117.6.1251 . 2289493 .
• Schneider C, King RM, Philipson L . Genes specifically expressed at growth arrest of mammalian cells . Cell . 54 . 6 . 787–93 . 1988 . 3409319 . 10.1016/S0092-8674(88)91065-3 . 37196421 .
• Sgorbissa A, Benetti R, Marzinotto S . Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis . J. Cell Sci. . 112 . 23. 4475–82 . 2000 . 10.1242/jcs.112.23.4475 . 10564664 . etal.
• Benetti R, Del Sal G, Monte M . The death substrate Gas2 binds m-calpain and increases susceptibility to p53-dependent apoptosis . EMBO J. . 20 . 11 . 2702–14 . 2001 . 11387205 . 10.1093/emboj/20.11.2702 . 125501 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Tsutsumi S, Kamata N, Vokes TJ . The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD) . Am. J. Hum. Genet. . 74 . 6 . 1255–61 . 2004 . 15124103 . 10.1086/421527 . 1182089 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Benetti R, Copetti T, Dell'Orso S . The calpain system is involved in the constitutive regulation of beta-catenin signaling functions . J. Biol. Chem. . 280 . 23 . 22070–80 . 2005 . 15817486 . 10.1074/jbc.M501810200 . etal. free .

Notes and References

1. Collavin L, Buzzai M, Saccone S, Bernard L, Federico C, DellaValle G, Brancolini C, Schneider C . cDNA characterization and chromosome mapping of the human GAS2 gene . Genomics . 48 . 2 . 265–9 . Jun 1998 . 9521882 . 10.1006/geno.1997.5172 .
2. Web site: Entrez Gene: GAS2 growth arrest-specific 2.