Nucleolar protein, member A1 explained

H/ACA ribonucleoprotein complex subunit 1 is a protein that in humans is encoded by the GAR1 gene.^{[1] [2]}

Function

This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene.^[2]

Interactions

Nucleolar protein, member A1 has been shown to interact with SMN1.^[3]

Further reading

• Fujii Y, Zhao FX, Fu SC, Nakai N, Lai CY . Stable preparation of aldose reductase isoenzymes from human placenta. . Protein Expr. Purif. . 2 . 5–6 . 420–5 . 1992 . 1821816 . 10.1016/1046-5928(91)90103-P .
• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O . Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. . Nature . 377 . 6547 Suppl . 3–174 . 1995 . 7566098 . .
• Ardell MD, Aragon I, Oliveira L, Porche GE, Burke E, Pittler SJ . The beta subunit of human rod photoreceptor cGMP-gated cation channel is generated from a complex transcription unit. . FEBS Lett. . 389 . 2 . 213–8 . 1996 . 8766832 . 10.1016/0014-5793(96)00588-1 . 37174534 . free .
• Pogacić V, Dragon F, Filipowicz W . Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10. . Mol. Cell. Biol. . 20 . 23 . 9028–40 . 2000 . 11074001 . 86556 . 10.1128/MCB.20.23.9028-9040.2000 .
• Pellizzoni L, Baccon J, Charroux B, Dreyfuss G . The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1. . Curr. Biol. . 11 . 14 . 1079–88 . 2001 . 11509230 . 10.1016/S0960-9822(01)00316-5 . 12392702 . free . 2001CBio...11.1079P .
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI . Directed proteomic analysis of the human nucleolus. . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free . 2002CBio...12....1A .
• Whitehead SE, Jones KW, Zhang X, Cheng X, Terns RM, Terns MP . Determinants of the interaction of the spinal muscular atrophy disease protein SMN with the dimethylarginine-modified box H/ACA small nucleolar ribonucleoprotein GAR1. . J. Biol. Chem. . 277 . 50 . 48087–93 . 2003 . 12244096 . 10.1074/jbc.M204551200 . free .
• Wang C, Meier UT . Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins. . EMBO J. . 23 . 8 . 1857–67 . 2005 . 15044956 . 394235 . 10.1038/sj.emboj.7600181 .
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 .
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M . Nucleolar proteome dynamics. . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Dragon F, Pogacić V, Filipowicz W . In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs . Mol Cell Biol . 20 . 9 . 3037–48 . May 2000 . 10757788 . 85579 . 10.1128/MCB.20.9.3037-3048.2000 .
2. Web site: Entrez Gene: NOLA1 nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs).
3. Pellizzoni L, Baccon J, Charroux B, Dreyfuss G . The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1 . Curr. Biol. . 11 . 14 . 1079–88 . Jul 2001 . 11509230 . 10.1016/S0960-9822(01)00316-5 . 12392702 . free . 2001CBio...11.1079P .