GANAB explained

Neutral alpha-glucosidase AB is an enzyme that in humans is encoded by the GANAB gene.^{[1] [2] [3]}

Interactions

GANAB has been shown to interact with PTPRC.^{[4] [5] [6]}

Further reading

• Feizi T, Larkin M . AIDS and glycosylation. . Glycobiology . 1 . 1 . 17–23 . 1992 . 2136376 . 10.1093/glycob/1.1.17 .
• Land A, Braakman I . Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum. . Biochimie . 83 . 8 . 783–90 . 2001 . 11530211 . 10.1016/S0300-9084(01)01314-1 . 1874/5091 . 13576808 . free .
• Fenouillet E, Gluckman JC . Effect of a glucosidase inhibitor on the bioactivity and immunoreactivity of human immunodeficiency virus type 1 envelope glycoprotein. . J. Gen. Virol. . 72 . 8 . 1919–26 . 1991 . 1678778 . 10.1099/0022-1317-72-8-1919 . free .
• Ratner L, vander Heyden N, Dedera D . Inhibition of HIV and SIV infectivity by blockade of alpha-glucosidase activity. . Virology . 181 . 1 . 180–92 . 1991 . 1704656 . 10.1016/0042-6822(91)90483-R .
• Dedera DA, Gu RL, Ratner L . Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function. . Virology . 187 . 1 . 377–82 . 1992 . 1736542 . 10.1016/0042-6822(92)90331-I .
• Murphy CI, Lennick M, Lehar SM, Beltz GA, Young E . Temporal expression of HIV-1 envelope proteins in baculovirus-infected insect cells: implications for glycosylation and CD4 binding. . Genet. Anal. Tech. Appl. . 7 . 6 . 160–71 . 1991 . 2076345 . 10.1016/0735-0651(90)90030-J .
• Kalyanaraman VS, Rodriguez V, Veronese F, Rahman R, Lusso P, DeVico AL, Copeland T, Oroszlan S, Gallo RC, Sarngadharan MG . Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1. . AIDS Res. Hum. Retroviruses . 6 . 3 . 371–80 . 1990 . 2187500 . 10.1089/aid.1990.6.371 .
• Shimizu H, Tsuchie H, Honma H, Yoshida K, Tsuruoka T, Ushijima H, Kitamura T . Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins. . Jpn. J. Med. Sci. Biol. . 43 . 3 . 75–87 . 1991 . 2283726 . 10.7883/yoken1952.43.75 . free .
• Leonard CK, Spellman MW, Riddle L, Harris RJ, Thomas JN, Gregory TJ . Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells. . J. Biol. Chem. . 265 . 18 . 10373–82 . 1990 . 10.1016/S0021-9258(18)86956-3 . 2355006 . free .
• Pal R, Hoke GM, Sarngadharan MG . Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1. . Proc. Natl. Acad. Sci. U.S.A. . 86 . 9 . 3384–8 . 1989 . 2541446 . 287137 . 10.1073/pnas.86.9.3384 . 1989PNAS...86.3384P . free .
• Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP . Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport. . J. Virol. . 63 . 6 . 2452–6 . 1989 . 2542563 . 250699 . 10.1128/jvi.63.6.2452-2456.1989.
• Kozarsky K, Penman M, Basiripour L, Haseltine W, Sodroski J, Krieger M . Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein. . J. Acquir. Immune Defic. Syndr. . 2 . 2 . 163–9 . 1989 . 2649653 .
• Walker BD, Kowalski M, Goh WC, Kozarsky K, Krieger M, Rosen C, Rohrschneider L, Haseltine WA, Sodroski J . Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine. . Proc. Natl. Acad. Sci. U.S.A. . 84 . 22 . 8120–4 . 1987 . 2825177 . 299490 . 10.1073/pnas.84.22.8120 . 1987PNAS...84.8120W . free .
• Robinson WE, Montefiori DC, Mitchell WM . Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis. . AIDS Res. Hum. Retroviruses . 3 . 3 . 265–82 . 1988 . 2829950 . 10.1089/aid.1987.3.265 .
• Gruters RA, Neefjes JJ, Tersmette M, de Goede RE, Tulp A, Huisman HG, Miedema F, Ploegh HL . Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. . Nature . 330 . 6143 . 74–7 . 1987 . 2959866 . 10.1038/330074a0 . 1987Natur.330...74G . 4270139 .
• Blough HA, Pauwels R, De Clercq E, Cogniaux J, Sprecher-Goldberger S, Thiry L . Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins. . Biochem. Biophys. Res. Commun. . 141 . 1 . 33–8 . 1987 . 3099781 . 10.1016/S0006-291X(86)80330-8 .
• Montefiori DC, Robinson WE, Mitchell WM . Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1. . Proc. Natl. Acad. Sci. U.S.A. . 85 . 23 . 9248–52 . 1988 . 3264072 . 282716 . 10.1073/pnas.85.23.9248 . 1988PNAS...85.9248M . free .
• Martiniuk F, Ellenbogen A, Hirschhorn R . Identity of neutral alpha-glucosidase AB and the glycoprotein processing enzyme glucosidase II. Biochemical and genetic studies. . J. Biol. Chem. . 260 . 2 . 1238–42 . 1985 . 10.1016/S0021-9258(20)71234-2 . 3881423 . free .

Notes and References

1. Treml K, Meimaroglou D, Hentges A, Bause E . The alpha- and beta-subunits are required for expression of catalytic activity in the hetero-dimeric glucosidase II complex from human liver . Glycobiology . 10 . 5 . 493–502 . May 2000 . 10764838 . 10.1093/glycob/10.5.493 . free .
2. Martiniuk F, Smith M, Ellenbogen A, Desnick RJ, Astrin K, Mitra J, Hirschhorn R . Assignment of the gene for neutral alpha-glucosidase AB to chromosome 11 . Cytogenet Cell Genet . 35 . 2 . 110–6 . July 1983 . 6342981 . 10.1159/000131851 . 46749795 .
3. Web site: Entrez Gene: GANAB glucosidase, alpha; neutral AB.
4. Arendt CW, Ostergaard HL . Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II . J. Biol. Chem. . 272 . 20 . 13117–25 . May 1997 . 9148925 . 10.1074/jbc.272.20.13117 . free .
5. Baldwin TA, Gogela-Spehar M, Ostergaard HL . Specific isoforms of the resident endoplasmic reticulum protein glucosidase II associate with the CD45 protein-tyrosine phosphatase via a lectin-like interaction . J. Biol. Chem. . 275 . 41 . 32071–6 . October 2000 . 10921916 . 10.1074/jbc.M003088200 . free .
6. Baldwin TA, Ostergaard HL . Developmentally regulated changes in glucosidase II association with, and carbohydrate content of, the protein tyrosine phosphatase CD45 . J. Immunol. . 167 . 7 . 3829–35 . October 2001 . 11564800 . 10.4049/jimmunol.167.7.3829 . free .