GALNT14 explained

Polypeptide N-acetylgalactosaminyltransferase 14 is an enzyme that in humans is encoded by the GALNT14 gene.^{[1] [2]}

GALNT14 (EC 2.4.1.41) belongs to a large subfamily of glycosyltransferases residing in the Golgi apparatus. GALNT enzymes catalyze the first step in the O-glycosylation of mammalian proteins by transferring N-acetyl-D-galactosamine (GalNAc) to peptide substrates.[supplied by OMIM]

SNPs on GALNT14 have been shown to be associated to the chemotherapy responses of patients with advanced hepatocellular carcinoma.^{[3] [4] [5] [6]}

Further reading

• Wu C, Yao G, Zou M . N-Acetylgalactosaminyltransferase 14, a novel insulin-like growth factor binding protein-3 binding partner . Biochem. Biophys. Res. Commun. . 357 . 2 . 360–5 . 2007 . 17434446 . 10.1016/j.bbrc.2007.03.153 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Clark HF, Gurney AL, Abaya E . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .

Notes and References

1. Wang H, Tachibana K, Zhang Y, Iwasaki H, Kameyama A, Cheng L, Guo J, Hiruma T, Togayachi A, Kudo T, Kikuchi N, Narimatsu H . Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14 . Biochem Biophys Res Commun . 300 . 3 . 738–44 . Dec 2002 . 12507512 . 10.1016/S0006-291X(02)02908-X .
2. Web site: Entrez Gene: GALNT14 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14).
3. Liang KH, Lin CC, Yeh CT . GALNT14 SNP as a potential predictor of response to combination chemotherapy using 5-FU, mitoxantrone and cisplatin in advanced HCC. . Pharmacogenomics . 12 . 7 . 1061–73 . Jul 2011 . 21635146 . 10.2217/pgs.11.43.
4. Yeh CT, Liang KH, Lin CC, Chang ML, Hsu CL, Hung CF . A single nucleotide polymorphism on the GALNT14 gene as an effective predictor of response to chemotherapy in advanced hepatocellular carcinoma. . Int J Cancer . 134 . 5 . 1214–1224 . Mar 2014 . 23959947 . 10.1002/ijc.28439. 1262943 . free .
5. Liang KH, Yang PC, Yeh CT . Genotyping the GALNT14 gene by joint analysis of two linked single nucleotide polymorphisms using liver tissues for clinical and geographical comparisons.. Oncol Lett . 25295111 . 10.3892/ol.2014.2507 . 8 . 5. Nov 2014 . 2215–2220 . 4186602.
6. Lin WR, Hsu CW, Chen YC, Chang ML, Liang KH, Huang YH, Yeh CT . GALNT14 genotype, α-fetoprotein and therapeutic side effects predict post-chemotherapy survival in patients with advanced hepatocellular carcinoma.. Mol Clin Oncol . 24940508 . 10.3892/mco.2014.294 . 2 . 4. Jul 2014 . 630–640 . 4051573.