GALNAC4S-6ST explained

Carbohydrate sulfotransferase 15 is an enzyme that in humans is encoded by the CHST15 gene.^{[1] [2] [3] [4]} It belongs to the N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase enzyme class.

Further reading

• Inoue H, Otsu K, Suzuki S, Nakanishi Y . Difference between N-acetylgalactosamine 4-sulfate 6-O-sulfotransferases from human serum and squid cartilage in specificity toward the terminal and interior portion of chondroitin sulfate. . J. Biol. Chem. . 261 . 10 . 4470–5 . 1986 . 10.1016/S0021-9258(17)38523-X . 3082866 . free .
• Verkoczy LK, Guinn B, Berinstein NL . Characterization of the human B cell RAG-associated gene, hBRAG, as a B cell receptor signal-enhancing glycoprotein dimer that associates with phosphorylated proteins in resting B cells. . J. Biol. Chem. . 275 . 28 . 20967–79 . 2000 . 10749872 . 10.1074/jbc.M001866200 . free .
• Yuki M, Yoshinaga K, Yamakawa H . Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer. . Oncol. Rep. . 7 . 6 . 1339–42 . 2000 . 11032940 . 10.3892/or.7.6.1339. etal.
• Sekiguchi T, Hirose E, Nakashima N . Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. . J. Biol. Chem. . 276 . 10 . 7246–57 . 2001 . 11073942 . 10.1074/jbc.M004389200 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ohtake S, Kimata K, Habuchi O . A unique nonreducing terminal modification of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase . J. Biol. Chem. . 278 . 40 . 38443–52 . 2003 . 12874280 . 10.1074/jbc.M306132200 . free .
• Deloukas P, Earthrowl ME, Grafham DV . The DNA sequence and comparative analysis of human chromosome 10 . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Sawada T, Fujii S, Nakano H . Synthesis of sulfated phenyl 2-acetamido-2-deoxy-D-galactopyranosides. 4-O-Sulfated phenyl 2-acetamido-2-deoxy-beta-D-galactopyranoside is a competitive acceptor that decreases sulfation of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase . Carbohydr. Res. . 340 . 12 . 1983–96 . 2005 . 16024005 . 10.1016/j.carres.2005.06.010 . etal.

Notes and References

1. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res . 5 . 1 . 31–9 . Aug 1998 . 9628581 . 10.1093/dnares/5.1.31 . free .
2. Verkoczy LK, Marsden PA, Berinstein NL . hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane glycoprotein potentially involved in the regulation of recombination activating gene 1 (RAG1) . Eur J Immunol . 28 . 9 . 2839–53 . Oct 1998 . 9754571 . 10.1002/(SICI)1521-4141(199809)28:09<2839::AID-IMMU2839>3.0.CO;2-6 . 21656270 . free .
3. Ohtake S, Ito Y, Fukuta M, Habuchi O . Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene . J Biol Chem . 276 . 47 . 43894–900 . Nov 2001 . 11572857 . 10.1074/jbc.M104922200 . free .
4. Web site: Entrez Gene: GALNAC4S-6ST B cell RAG associated protein.