GAL3ST1 explained

Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.^{[1] [2] [3]}

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.^[3]

Further reading

• Siegrist HP . Age-dependent modulation of 3'-phosphoadenosine-5'-phosphosulfate-galactosylceramide sulfotransferase by lipids extracted from the microsomal membranes and artificial lipid mixtures . Biochim. Biophys. Acta . 489 . 1 . 58–63 . 1977 . 911873 . 10.1016/0005-2760(77)90231-4. vanc. Jutzi H . Steck AJ . 3 . Burkart . T . Wiesmann . U . Herschkowitz . N .
• Stein C . Cloning and expression of human arylsulfatase A . J. Biol. Chem. . 264 . 2 . 1252–9 . 1989 . 2562955 . vanc. Gieselmann V . Kreysing J . 3 . Schmidt . B . Pohlmann . R . Waheed . A . Meyer . HE . O'Brien . JS . Von Figura . K . 10.1016/S0021-9258(19)85079-2 . free .
• Fleischer B, Zambrano F . Localization of cerebroside-sulfotransferase activity in the Golgi apparatus of rat kidney . Biochem. Biophys. Res. Commun. . 52 . 3 . 951–8 . 1973 . 4710574 . 10.1016/0006-291X(73)91029-2 .
• Farrell DF, McKhann GM . Characterization of cerebroside sulfotransferase from rat brain . J. Biol. Chem. . 246 . 15 . 4694–702 . 1971 . 10.1016/S0021-9258(18)61991-X . 5562350 . free .
• Costantino-Ceccarini E . Distribution of lipid synthesizing enzymes, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteins in rat forebrain subfractions during development . Neurochem. Res. . 7 . 1 . 1–12 . 1982 . 6280086 . 10.1007/BF00965064 . vanc. Waehneldt TV . Ginalski H . 3 . Burgisser . Philippe . Reigner . Jacqueline . Matthieu . Jean-Marie . 32069166 .
• Benjamins JA, Hadden T, Skoff RP . Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain . J. Neurochem. . 38 . 1 . 233–41 . 1982 . 6955451 . 10.1111/j.1471-4159.1982.tb10875.x . 23693243 .
• Honke K . Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells . J. Biochem. . 119 . 3 . 421–7 . 1996 . 8830034 . 10.1093/oxfordjournals.jbchem.a021258. vanc. Yamane M . Ishii A . 3 . Kobayashi . T . Makita . A .
• Tsuda M . Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene . Eur. J. Biochem. . 267 . 9 . 2672–9 . 2000 . 10785389 . 10.1046/j.1432-1327.2000.01281.x . vanc. Egashira M . Niikawa N . 3 . Wada . Yoshinao . Honke . Koichi . free.
• Eckhardt M, Fewou SN, Ackermann I, Gieselmann V . N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase . Biochem. J. . 368 . Pt 1 . 317–24 . 2002 . 12175333 . 10.1042/BJ20020946 . 1222978 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Collins JE . A genome annotation-driven approach to cloning the human ORFeome . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 10.1186/gb-2004-5-10-r84 . 545604 . vanc. Wright CL . Edwards CA . 3 . Davis . Matthew P . Grinham . James A . Cole . Charlotte G . Goward . Melanie E . Aguado . Begoña . Mallya . Meera . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .

Notes and References

1. Toward a complete human genome sequence . Genome Res . 8 . 11 . 1097–108 . Jan 1999 . 9847074 . 10.1101/gr.8.11.1097. Sanger Centre . The . Washington University Genome Sequencing Cente . The . free .
2. Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y . Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase . J Biol Chem . 272 . 8 . 4864–8 . Apr 1997 . 9030544 . 10.1074/jbc.272.8.4864 . free .
3. Web site: Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1.