GAF domain explained
| Symbol: | GAF |
| GAF domain |
| Pfam: | PF01590 |
| Pfam Clan: | CL0161 |
| Interpro: | IPR003018 |
| Smart: | GAF |
| Scop: | 1fl4 |
The GAF domain is a type of protein domain that is found in a wide range of proteins from all species.[1] The GAF domain is named after some of the proteins it is found in: cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. The first structure of a GAF domain solved by Ho and colleagues showed that this domain shared a similar fold with the PAS domain.[2] In mammals, GAF domains are found in five members of the cyclic nucleotide phosphodiesterase superfamily: PDE2, PDE5, and PDE6 which bind cGMP to the GAF domain, PDE10 which binds cAMP, and PDE11 which binds both cGMP and cAMP.[3] [4]
Examples
Human proteins containing this domain include:
Notes and References
- Aravind L, Ponting CP . The GAF domain: an evolutionary link between diverse phototransducing proteins . Trends in Biochemical Sciences . 22 . 12 . 458–9 . December 1997 . 9433123 . 10.1016/S0968-0004(97)01148-1 .
- Ho YS, Burden LM, Hurley JH . Structure of the GAF domain, a ubiquitous signaling motif and a new class of cyclic GMP receptor . The EMBO Journal . 19 . 20 . 5288–99 . October 2000 . 11032796 . 314001 . 10.1093/emboj/19.20.5288 .
- Fawcett L, Baxendale R, Stacey P, McGrouther C, Harrow I, Soderling S, Hetman J, Beavo JA, Phillips SC . Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A . Proceedings of the National Academy of Sciences of the United States of America . 97 . 7 . 3702–7 . March 2000 . 10725373 . 16303 . 10.1073/pnas.050585197 . 2000PNAS...97.3702F . 121956 . free .
- Book: Schultz JE . CGMP: Generators, Effectors and Therapeutic Implications . Structural and biochemical aspects of tandem GAF domains . 191 . 191 . 93–109 . 2009 . 19089327 . 10.1007/978-3-540-68964-5_6 . 978-3-540-68960-7 . Handbook of Experimental Pharmacology .
