GAD2 explained

Glutamate decarboxylase 2 is an enzyme that in humans is encoded by the GAD2 gene.^[1]

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff-person syndrome.^[2]

Interactions

GAD2 has been shown to interact with GAD1.^[3]

See also

• Glutamate decarboxylase

Notes and References

1. Cram DS, Barnett LD, Joseph JL, Harrison LC . Cloning and partial nucleotide sequence of human glutamic acid decarboxylase cDNA from brain and pancreatic islets . Biochem. Biophys. Res. Commun. . 176 . 3 . 1239–44 . July 1991 . 2039509 . 10.1016/0006-291X(91)90418-7 .
2. Web site: Entrez Gene: GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa).
3. Dirkx R, Thomas A, Li L, Lernmark A, Sherwin RS, De Camilli P, Solimena M . Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase . J. Biol. Chem. . 270 . 5 . 2241–6 . February 1995 . 7836456 . 10.1074/jbc.270.5.2241 . free .