GABRR2 explained

Gamma-aminobutyric acid receptor subunit rho-2 is a protein that in humans is encoded by the GABRR2 gene.^{[1] [2]}

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR2 is a member of the rho subunit family.^[2]

See also

• GABA_A-ρ receptor

Further reading

• Hackam AS, Wang TL, Guggino WB, Cutting GR . The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction. . J. Biol. Chem. . 272 . 21 . 13750–13757 . 1997 . 9153229 . 10.1074/jbc.272.21.13750 . free .
• Kusama T, Hatama K, Sakurai M . Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation. . Neurosci. Lett. . 255 . 1 . 17–20 . 1999 . 9839716 . 10.1016/S0304-3940(98)00696-X . 12933301 . etal.
• Bailey ME, Albrecht BE, Johnson KJ, Darlison MG . Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3. . Biochim. Biophys. Acta . 1447 . 2–3 . 307–312 . 1999 . 10542332 . 10.1016/S0167-4781(99)00167-0.
• Billups D, Hanley JG, Orme M . GABAC receptor sensitivity is modulated by interaction with MAP1B . J. Neurosci. . 20 . 23 . 8643–8650 . 2001 . 11102469 . 10.1523/jneurosci.20-23-08643.2000. 6773065 . etal. free .
• Sedelnikova A, Weiss DS . Phosphorylation of the recombinant rho1 GABA receptor . Int. J. Dev. Neurosci. . 20 . 3–5 . 237–246 . 2002 . 12175859 . 10.1016/S0736-5748(02)00037-0 . 54402119 .
• Croci C, Brändstatter JH, Enz R . ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2 . J. Biol. Chem. . 278 . 8 . 6128–6135 . 2003 . 12431995 . 10.1074/jbc.M205162200 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gamel-Didelon K, Kunz L, Fohr KJ . Molecular and physiological evidence for functional gamma-aminobutyric acid (GABA)-C receptors in growth hormone-secreting cells . J. Biol. Chem. . 278 . 22 . 20192–20195 . 2003 . 12660236 . 10.1074/jbc.M301729200 . etal. free .
• Mungall AJ, Palmer SA, Sims SK . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–811 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.

Notes and References

1. Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR. Huda Zoghbi . Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4 . Genomics . 12 . 4 . 801–806 . May 1992 . 1315307 . 10.1016/0888-7543(92)90312-G .
2. Web site: Entrez Gene: GABRR2 gamma-aminobutyric acid (GABA) receptor, rho 2.