GABRR1 explained

Gamma-aminobutyric acid receptor subunit rho-1 is a protein that in humans is encoded by the GABRR1 gene.^{[1] [2] [3]}

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family.^[3]

See also

• GABA_A-ρ receptor

Further reading

• Wang TL, Hackam A, Guggino WB, Cutting GR . A single histidine residue is essential for zinc inhibition of GABA rho 1 receptors . J. Neurosci. . 15 . 11 . 7684–7691 . 1995 . 7472519 . 6578093 . 10.1523/jneurosci.15-11-07684.1995.
• Hackam AS, Wang TL, Guggino WB, Cutting GR . The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction . J. Biol. Chem. . 272 . 21 . 13750–13757 . 1997 . 9153229 . 10.1074/jbc.272.21.13750 . free .
• Kusama T, Hatama K, Sakurai M . Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation . Neurosci. Lett. . 255 . 1 . 17–20 . 1999 . 9839716 . 10.1016/S0304-3940(98)00696-X . 12933301 . etal.
• Hanley JG, Koulen P, Bedford F . The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses . Nature . 397 . 6714 . 66–69 . 1999 . 9892354 . 10.1038/16258 . 1999Natur.397...66H . 4421437 . etal.
• Bailey ME, Albrecht BE, Johnson KJ, Darlison MG . Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3 . Biochim. Biophys. Acta . 1447 . 2–3 . 307–312 . 1999 . 10542332 . 10.1016/S0167-4781(99)00167-0.
• Hanley JG, Jones EM, Moss SJ . GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1 . J. Biol. Chem. . 275 . 2 . 840–846 . 2000 . 10625616 . 10.1074/jbc.275.2.840 . free .
• Filippova N, Sedelnikova A, Zong Y . Regulation of recombinant gamma-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C . Mol. Pharmacol. . 57 . 5 . 847–856 . 2000 . 10779366 . etal.
• Billups D, Hanley JG, Orme M . GABAC receptor sensitivity is modulated by interaction with MAP1B . J. Neurosci. . 20 . 23 . 8643–8650 . 2001 . 11102469 . 6773065 . 10.1523/jneurosci.20-23-08643.2000. etal.
• Wang QW, Li ZW, Wang F, Yang JQ . Modulation by divalent cations of GABA rho 1 receptor from human retina expressed in Xenopus oocytes . Biomed. Environ. Sci. . 14 . 4 . 269–277 . 2002 . 11862606 .
• Sedelnikova A, Weiss DS . Phosphorylation of the recombinant rho1 GABA receptor . Int. J. Dev. Neurosci. . 20 . 3–5 . 237–246 . 2002 . 12175859 . 10.1016/S0736-5748(02)00037-0 . 54402119 .
• Torres VI, Weiss DS . Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening . J. Biol. Chem. . 277 . 46 . 43741–43748 . 2003 . 12226075 . 10.1074/jbc.M202007200 . free .
• Croci C, Brändstatter JH, Enz R . ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2 . J. Biol. Chem. . 278 . 8 . 6128–6135 . 2003 . 12431995 . 10.1074/jbc.M205162200 . free .
• Mungall AJ, Palmer SA, Sims SK . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–811 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . etal. free .
• Boué-Grabot E, Emerit MB, Toulmé E . Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels . J. Biol. Chem. . 279 . 8 . 6967–6975 . 2004 . 14660627 . 10.1074/jbc.M307772200 . etal. free .
• Martínez-Torres A, Miledi R . A single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism . Arch. Med. Res. . 35 . 3 . 194–198 . 2004 . 15163459 . 10.1016/j.arcmed.2003.12.002 .
• Sedelnikova A, Smith CD, Zakharkin SO . Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete model . J. Biol. Chem. . 280 . 2 . 1535–1542 . 2005 . 15548535 . 10.1074/jbc.M409908200 . etal. free .
• Song XQ, Meng F, Ramsey DJ . The GABA rho1 subunit interacts with a cellular retinoic acid binding protein in mammalian retina . Neuroscience . 136 . 2 . 467–475 . 2006 . 16198491 . 10.1016/j.neuroscience.2005.08.018 . 37043103 . etal.

Notes and References

1. Cutting GR, Lu L, O'Hara BF, Kasch LM, Montrose-Rafizadeh C, Donovan DM, Shimada S, Antonarakis SE, Guggino WB, Uhl GR . Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina . Proc Natl Acad Sci U S A . 88 . 7 . 2673–2677 . May 1991 . 1849271 . 51300 . 10.1073/pnas.88.7.2673 . 1991PNAS...88.2673C . etal. free .
2. Huda Zoghbi . Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR . Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4 . Genomics . 12 . 4 . 801–806 . May 1992 . 1315307 . 10.1016/0888-7543(92)90312-G .
3. Web site: Entrez Gene: GABRR1 gamma-aminobutyric acid (GABA) receptor, rho 1.